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Anti-Tumor Drug-Loaded Oxygen Nanobubbles for the Degradation of HIF-1α and the Upregulation of Reactive Oxygen Species in Tumor Cells

1
School of Integrative Engineering, Chung-Ang University, Seoul 06974, Korea
2
Center for Biomaterials, Korea Institute of Science and Technology, Seoul 02792, Korea
3
Department of Bionano Technology, Hanyang University, Seoul 426-791, Korea
4
Department of Bionano Engineering, Hanyang University, Ansan 426-791, Korea
*
Author to whom correspondence should be addressed.
These authors contributed equally.
Cancers 2019, 11(10), 1464; https://doi.org/10.3390/cancers11101464
Received: 17 August 2019 / Revised: 17 September 2019 / Accepted: 27 September 2019 / Published: 29 September 2019
Hypoxia is a key concern during the treatment of tumors, and hypoxia-inducible factor 1 alpha (HIF-1α) has been associated with increased tumor resistance to therapeutic modalities. In this study, doxorubicin-loaded oxygen nanobubbles (Dox/ONBs) were synthesized, and the effectiveness of drug delivery to MDA-MB-231 breast cancer and HeLa cells was evaluated. Dox/ONBs were characterized using optical and fluorescence microscopy, and size measurements were performed through nanoparticle tracking analysis (NTA). The working mechanism of Dox was evaluated using reactive oxygen species (ROS) assays, and cellular penetration was assessed with confocal microscopy. Hypoxic conditions were established to assess the effect of Dox/ONBs under hypoxic conditions compared with normoxic conditions. Our results indicate that Dox/ONBs are effective for drug delivery, enhancing oxygen levels, and ROS generation in tumor-derived cell lines. View Full-Text
Keywords: doxorubicin; drug delivery; oxygen nanobubbles; hypoxia; hypoxia-inducible factor 1 alpha doxorubicin; drug delivery; oxygen nanobubbles; hypoxia; hypoxia-inducible factor 1 alpha
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Khan, M.S.; Hwang, J.; Lee, K.; Choi, Y.; Seo, Y.; Jeon, H.; Hong, J.W.; Choi, J. Anti-Tumor Drug-Loaded Oxygen Nanobubbles for the Degradation of HIF-1α and the Upregulation of Reactive Oxygen Species in Tumor Cells. Cancers 2019, 11, 1464.

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