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Autophagy Function and Dysfunction: Potential Drugs as Anti-Cancer Therapy

Department of Precision Medicine, University of Campania “L. Vanvitelli”, via L. De Crecchio, 7, 80138 Naples, Italy
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Cancers 2019, 11(10), 1465; https://doi.org/10.3390/cancers11101465
Received: 17 July 2019 / Revised: 25 September 2019 / Accepted: 26 September 2019 / Published: 29 September 2019
(This article belongs to the Special Issue Apoptosis in Cancer)
Autophagy is a highly conserved catabolic and energy-generating process that facilitates the degradation of damaged organelles or intracellular components, providing cells with components for the synthesis of new ones. Autophagy acts as a quality control system, and has a pro-survival role. The imbalance of this process is associated with apoptosis, which is a “positive” and desired biological choice in some circumstances. Autophagy dysfunction is associated with several diseases, including neurodegenerative disorders, cardiomyopathy, diabetes, liver disease, autoimmune diseases, and cancer. Here, we provide an overview of the regulatory mechanisms underlying autophagy, with a particular focus on cancer and the autophagy-targeting drugs currently approved for use in the treatment of solid and non-solid malignancies. View Full-Text
Keywords: autophagy; cancer; apoptosis; chloroquine; mTOR inhibitors; drugs autophagy; cancer; apoptosis; chloroquine; mTOR inhibitors; drugs
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Cuomo, F.; Altucci, L.; Cobellis, G. Autophagy Function and Dysfunction: Potential Drugs as Anti-Cancer Therapy. Cancers 2019, 11, 1465.

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