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Open AccessArticle

Proton Beam Therapy Combined with Intra-Arterial Infusion Chemotherapy for Stage IV Adenoid Cystic Carcinoma of the Base of the Tongue

1
Department of Radiation Oncology, Southern Tohoku Proton Therapy Center, 7-172, Yatsuyamada, Koriyama, Fukushima 963-8052, Japan
2
Department of Oral and Maxillofacial Surgery, Yokohama City University Graduate School of Medicine, 3-9, Fukuura, Kanazawa, Yokohama, Kanagawa 236-0004, Japan
3
Department of Radiology, Mie University Hospital, 2-174, Edobashi Tsu, Mie 514-8507, Japan
4
Department of Radiation Oncology, Ise red cross hospital, 1-471-2, Funae, Ise, Mie 516-8512, Japan
*
Author to whom correspondence should be addressed.
Cancers 2019, 11(10), 1413; https://doi.org/10.3390/cancers11101413
Received: 17 August 2019 / Revised: 12 September 2019 / Accepted: 20 September 2019 / Published: 22 September 2019
(This article belongs to the Collection Drug Resistance and Novel Therapies in Cancers)
Adenoid cystic carcinoma (ACC) is a very rare epithelial tumor of the salivary glands. Surgical resection is considered to be a standard therapy. However, the optimal treatment strategy for managing advanced cases has not yet been established. This study evaluated the efficacy and toxicity of proton beam therapy (PBT) combined with selective intra-arterial infusion chemotherapy (IAIC) using weekly cisplatin for locally advanced ACC of the base of the tongue. Between March 2009 and February 2018, 15 patients were treated. The median follow-up duration was 56 (range: 15–116) months. The 5-year local control and overall survival rates were 89% and 76%, respectively. With regard to late toxicities, grade 2 osteoradionecrosis was found in one patient and grade 5 pharyngeal necrosis was observed in one patient. Considering most cases were significantly advanced and inoperable, this therapy was effective in controlling the primary tumor, preserving function and maintaining the quality of life. Although improvements are needed to reduce adverse events, PBT in combination with IAIC can be a treatment option for locally advanced ACC of the base of the tongue. View Full-Text
Keywords: proton beam therapy; adenoid cystic carcinoma; intra-arterial infusion chemotherapy; the base of the tongue; chemoradiotherapy proton beam therapy; adenoid cystic carcinoma; intra-arterial infusion chemotherapy; the base of the tongue; chemoradiotherapy
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Takayama, K.; Kato, T.; Nakamura, T.; Azami, Y.; Ono, T.; Suzuki, M.; Takada, A.; Yamaguchi, H.; Seto, I.; Nakasato, T.; Wada, H.; Kikuchi, Y.; Mitsudo, K.; Fuwa, N.; Murakami, M. Proton Beam Therapy Combined with Intra-Arterial Infusion Chemotherapy for Stage IV Adenoid Cystic Carcinoma of the Base of the Tongue. Cancers 2019, 11, 1413.

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