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Micromachines 2016, 7(2), 29;

Opto-Microfluidic Immunosensors: From Colorimetric to Plasmonic

Department of Mechanical Engineering, National Taiwan University, Taipei 10617, Taiwan
These authors contributed equally to this work.
Author to whom correspondence should be addressed.
Academic Editors: Ian Papautsky and Nam-Trung Nguyen
Received: 13 December 2015 / Revised: 25 January 2016 / Accepted: 4 February 2016 / Published: 15 February 2016
(This article belongs to the Special Issue Optofluidics 2015)
Full-Text   |   PDF [3032 KB, uploaded 16 February 2016]   |  


Optical detection has long been the most popular technique in immunosensing. Recent developments in the synthesis of luminescent probes and the fabrication of novel nanostructures enable more sensitive and efficient optical detection, which can be miniaturized and integrated with microfluidics to realize compact lab-on-a-chip immunosensors. These immunosensors are portable, economical and automated, but their sensitivity is not compromised. This review focuses on the incorporation and implementation of optical detection and microfluidics in immunosensors; it introduces the working principles of each optical detection technique and how it can be exploited in immunosensing. The recent progress in various opto-microfluidic immunosensor designs is described. Instead of being comprehensive to include all opto-microfluidic platforms, the report centers on the designs that are promising for point-of-care immunosensing diagnostics, in which ease of use, stability and cost-effective fabrication are emphasized. View Full-Text
Keywords: optical detection; microfluidics; immunosensing optical detection; microfluidics; immunosensing

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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He, J.-L.; Wang, D.-S.; Fan, S.-K. Opto-Microfluidic Immunosensors: From Colorimetric to Plasmonic. Micromachines 2016, 7, 29.

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