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Advanced Neural Interface toward Bioelectronic Medicine Enabled by Micro-Patterned Shape Memory Polymer

Robotics Engineering, Daegu Gyeongbuk Institute of Science and Technology (DGIST), Daegu 42899, Korea
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Academic Editor: Yijae Lee
Micromachines 2021, 12(6), 720; https://doi.org/10.3390/mi12060720
Received: 2 June 2021 / Revised: 11 June 2021 / Accepted: 17 June 2021 / Published: 19 June 2021
(This article belongs to the Special Issue Neural (Nerve) Electrode)
Recently, methods for the treatment of chronic diseases and disorders through the modulation of peripheral and autonomic nerves have been proposed. To investigate various treatment methods and results, experiments are being conducted on animals such as rabbits and rat. However the diameter of the targeted nerves is small (several hundred μm) and it is difficult to modulate small nerves. Therefore, a neural interface that is stable, easy to implant into small nerves, and is biocompatible is required. Here, to develop an advanced neural interface, a thiol-ene/acrylate-based shape memory polymer (SMP) was fabricated with a double clip design. This micro-patterned design is able to be implanted on a small branch of the sciatic nerve, as well as the parasympathetic pelvic nerve, using the shape memory effect (SME) near body temperature. Additionally, the IrO2 coated neural interface was implanted on the common peroneal nerve in order to perform electrical stimulation and electroneurography (ENG) recording. The results demonstrate that the proposed neural interface can be used for the modulation of the peripheral nerve, including the autonomic nerve, towards bioelectronic medicine. View Full-Text
Keywords: neural interface; shape memory polymer; neuromodulation; neural recoding; neural stimulation; bioelectronic medicine neural interface; shape memory polymer; neuromodulation; neural recoding; neural stimulation; bioelectronic medicine
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MDPI and ACS Style

Cho, Y.; Shin, H.; Park, J.; Lee, S. Advanced Neural Interface toward Bioelectronic Medicine Enabled by Micro-Patterned Shape Memory Polymer. Micromachines 2021, 12, 720. https://doi.org/10.3390/mi12060720

AMA Style

Cho Y, Shin H, Park J, Lee S. Advanced Neural Interface toward Bioelectronic Medicine Enabled by Micro-Patterned Shape Memory Polymer. Micromachines. 2021; 12(6):720. https://doi.org/10.3390/mi12060720

Chicago/Turabian Style

Cho, Youngjun, Heejae Shin, Jaeu Park, and Sanghoon Lee. 2021. "Advanced Neural Interface toward Bioelectronic Medicine Enabled by Micro-Patterned Shape Memory Polymer" Micromachines 12, no. 6: 720. https://doi.org/10.3390/mi12060720

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