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Micromachines 2019, 10(2), 103; https://doi.org/10.3390/mi10020103

Multi-Stage Particle Separation based on Microstructure Filtration and Dielectrophoresis

Key Laboratory of Biorheological Science and Technology, Chongqing University, Ministry of Education, Bioengineering College, Chongqing University, Chongqing 400030, China
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Received: 30 December 2018 / Revised: 27 January 2019 / Accepted: 29 January 2019 / Published: 31 January 2019
(This article belongs to the Special Issue Micro/Nano-Chip Electrokinetics, Volume III)
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Abstract

Particle separation is important in chemical and biomedical analysis. Among all particle separation approaches, microstructure filtration which based particles size difference has turned into one of the most commonly methods. By controlling the movement of particles, dielectrophoresis has also been widely adopted in particle separation. This work presents a microfluidic device which combines the advantages of microfilters and dielectrophoresis to separate micro-particles and cells. A three-dimensional (3D) model was developed to calculate the distributions of the electric field gradient at the two filter stages. Polystyrene particles with three different sizes were separated by micropillar array structure by applying a 35-Vpp AC voltage at 10 KHz. The blocked particles were pushed off the filters under the negative dielectrophoretic force and drag force. A mixture of Haematococcus pluvialis cells and Bracteacoccus engadinensis cells with different sizes were also successfully separated by this device, which proved that the device can separate both biological samples and polystyrene particles. View Full-Text
Keywords: Microfilter; Dielectrophoresis; Particle separation, micropillar Microfilter; Dielectrophoresis; Particle separation, micropillar
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Yin, D.; Zhang, X.; Han, X.; Yang, J.; Hu, N. Multi-Stage Particle Separation based on Microstructure Filtration and Dielectrophoresis. Micromachines 2019, 10, 103.

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