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Open AccessCommentary

Yessotoxin as a Tool to Study Induction of Multiple Cell Death Pathways

The Norwegian School of Veterinary Science, P.O. Box 8146 Dep., N-0033 Oslo, Norway
Toxins 2012, 4(7), 568-579; https://doi.org/10.3390/toxins4070568
Received: 14 May 2012 / Revised: 14 July 2012 / Accepted: 21 July 2012 / Published: 23 July 2012
(This article belongs to the Special Issue Novel Properties of Well-Characterized Toxins)
This work proposes to use the marine algal toxin yessotoxin (YTX) to establish reference model experiments to explore medically valuable effects from induction of multiple cell death pathways. YTX is one of few toxins reported to make such induction. It is a small molecule compound which at low concentrations can induce apoptosis in primary cultures, many types of cells and cell lines. It can also induce a non-apoptotic form of programmed cell death in BC3H1 myoblast cell lines. The present contribution reviews arguments that this type of induction may have principal interest outside this particular example. One principal effect of medical interest may be that cancer cells will not so easily adapt to the synergistic effects from induction of more than one death pathway as compared to induction of only apoptosis. View Full-Text
Keywords: apoptosis; paraptosis; multiple signalling pathways; yessotoxin; cancer; neurodegenerative diseases apoptosis; paraptosis; multiple signalling pathways; yessotoxin; cancer; neurodegenerative diseases
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Korsnes, M.S. Yessotoxin as a Tool to Study Induction of Multiple Cell Death Pathways. Toxins 2012, 4, 568-579.

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