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Common Mechanism for Target Specificity of Protein- and DNA-Targeting ADP-Ribosyltransferases

by 1 and 2,3,4,*
1
Faculty of Science, Japan Women’s University, 2-8-1 Mejirodai, Bunkyo-ku, Tokyo 112-8681, Japan
2
Faculty of Life Sciences, Kyoto Sangyo University, Kamigamo-motoyama, Kita-ku, Kyoto 603-8555, Japan
3
Institute for Protein Dynamics, Kyoto Sangyo University, Kamigamo-motoyama, Kita-ku, Kyoto 603-8555, Japan
4
Center for Molecular Research in Infectious Diseases, Kyoto Sangyo University, Kamigamo-motoyama, Kita-ku, Kyoto 603-8555, Japan
*
Author to whom correspondence should be addressed.
Toxins 2021, 13(1), 40; https://doi.org/10.3390/toxins13010040
Received: 13 December 2020 / Revised: 1 January 2021 / Accepted: 3 January 2021 / Published: 7 January 2021
(This article belongs to the Special Issue Structure and Function of Bacterial ADP-Ribosylation Toxins)
Many bacterial pathogens utilize ADP-ribosyltransferases (ARTs) as virulence factors. The critical aspect of ARTs is their target specificity. Each individual ART modifies a specific residue of its substrates, which could be proteins, DNA, or antibiotics. However, the mechanism underlying this specificity is poorly understood. Here, we review the substrate recognition mechanism and target residue specificity based on the available complex structures of ARTs and their substrates. We show that there are common mechanisms of target residue specificity among protein- and DNA-targeting ARTs. View Full-Text
Keywords: ADP-ribosyltransferase; substrate recognition; target residue specificity; complex structure of enzyme and substrate ADP-ribosyltransferase; substrate recognition; target residue specificity; complex structure of enzyme and substrate
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MDPI and ACS Style

Yoshida, T.; Tsuge, H. Common Mechanism for Target Specificity of Protein- and DNA-Targeting ADP-Ribosyltransferases. Toxins 2021, 13, 40. https://doi.org/10.3390/toxins13010040

AMA Style

Yoshida T, Tsuge H. Common Mechanism for Target Specificity of Protein- and DNA-Targeting ADP-Ribosyltransferases. Toxins. 2021; 13(1):40. https://doi.org/10.3390/toxins13010040

Chicago/Turabian Style

Yoshida, Toru; Tsuge, Hideaki. 2021. "Common Mechanism for Target Specificity of Protein- and DNA-Targeting ADP-Ribosyltransferases" Toxins 13, no. 1: 40. https://doi.org/10.3390/toxins13010040

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