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Amelioration of Hyperglycaemia, Oxidative Stress and Dyslipidaemia in Alloxan-Induced Diabetic Wistar Rats Treated with Probiotic and Vitamin C

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Department of Veterinary Physiology, Ahmadu Bello University, c/o P.O. Box 216 Samaru, 810006 Zaria, Nigeria
2
Biochemistry Division, National Veterinary Research Institute, 930103 Vom, Nigeria
*
Author to whom correspondence should be addressed.
Nutrients 2016, 8(5), 151; https://doi.org/10.3390/nu8050151
Received: 17 December 2015 / Revised: 16 February 2016 / Accepted: 1 March 2016 / Published: 5 May 2016
Clinical and experimental evidence suggests that hyperglycaemia is responsible for the oxidative stress in diabetes mellitus. The study was designed to investigate the comparative effects of probiotic and vitamin C (Vit-C) treatments on hyperglycaemia, oxidative stress and dyslipidaemia in alloxan-induced diabetic rats. Type 1 diabetes (T1DM) was induced in male Wistar rats by a single intraperitoneal (i.p.) injection of alloxan (150 mg/kg). Six groups of the animals received the following treatment regimens for four weeks: (1) Normal saline, per os; (2) alloxan (150 mg/kg, i.p.); (3) alloxan (150 mg/kg) + insulin (4 U/kg, subcutaneously); (4) alloxan (150 mg/kg) + probiotic (4.125 × 106 CFU/100 mL per os); (5) alloxan (150 mg/kg) + Vit-C (100 mg/kg, i.m.); (6) alloxan (150 mg/kg) + probiotic (4.125 × 106 CFU/100 mL per os) + Vit-C (100 mg/kg, intramuscularly). Probiotic + Vit-C decreased (p < 0.05) blood glucose concentration in diabetic treated group, when compared with the untreated diabetic group. Probiotic + Vit-C reduced malondialdehyde concentration, in the serum, brain and kidneys, respectively, but increased the activity of antioxidant enzymes. Probiotic and Vit-C may be more effective than Vit-C alone, in ameliorating hyperglycaemia, oxidative stress and dyslipidaemia in alloxan-induced diabetic rats. View Full-Text
Keywords: dyslipidaemia; hyperglycaemia; oxidative stress; type 1 diabetes; wistar rats dyslipidaemia; hyperglycaemia; oxidative stress; type 1 diabetes; wistar rats
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Aluwong, T.; Ayo, J.O.; Kpukple, A.; Oladipo, O.O. Amelioration of Hyperglycaemia, Oxidative Stress and Dyslipidaemia in Alloxan-Induced Diabetic Wistar Rats Treated with Probiotic and Vitamin C. Nutrients 2016, 8, 151.

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