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Body Position Modulates Gastric Emptying and Affects the Post-Prandial Rise in Plasma Amino Acid Concentrations Following Protein Ingestion in Humans

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Department of Human Movement Sciences, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre+, P.O. Box 616, Maastricht 6200 MD, The Netherlands
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Department of Surgery, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre+, P.O. Box 616, Maastricht 6200 MD, The Netherlands
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Department of Clinical Genetics, Maastricht University Medical Centre+, P.O. Box 616, Maastricht 6200 MD, The Netherlands
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Author to whom correspondence should be addressed.
Nutrients 2016, 8(4), 221; https://doi.org/10.3390/nu8040221
Received: 14 March 2016 / Revised: 5 April 2016 / Accepted: 8 April 2016 / Published: 13 April 2016
Dietary protein digestion and amino acid absorption kinetics determine the post-prandial muscle protein synthetic response. Body position may affect gastrointestinal function and modulate the post-prandial rise in plasma amino acid availability. We aimed to assess the impact of body position on gastric emptying rate and the post-prandial rise in plasma amino acid concentrations following ingestion of a single, meal-like amount of protein. In a randomized, cross-over design, eight healthy males (25 ± 2 years, 23.9 ± 0.8 kg·m−2) ingested 22 g protein and 1.5 g paracetamol (acetaminophen) in an upright seated position (control) and in a −20° head-down tilted position (inversion). Blood samples were collected during a 240-min post-prandial period and analyzed for paracetamol and plasma amino acid concentrations to assess gastric emptying rate and post-prandial amino acid availability, respectively. Peak plasma leucine concentrations were lower in the inversion compared with the control treatment (177 ± 15 vs. 236 ± 15 mmol·L−1, p < 0.05), which was accompanied by a lower plasma essential amino acid (EAA) response over 240 min (31,956 ± 6441 vs. 50,351 ± 4015 AU; p < 0.05). Peak plasma paracetamol concentrations were lower in the inversion vs. control treatment (5.8 ± 1.1 vs. 10.0 ± 0.6 mg·L−1, p < 0.05). Gastric emptying rate and post-prandial plasma amino acid availability are significantly decreased after protein ingestion in a head-down tilted position. Therefore, upright body positioning should be considered when aiming to augment post-prandial muscle protein accretion in both health and disease. View Full-Text
Keywords: protein; body position; digestion; gastric emptying protein; body position; digestion; gastric emptying
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MDPI and ACS Style

Holwerda, A.M.; Lenaerts, K.; Bierau, J.; Van Loon, L.J.C. Body Position Modulates Gastric Emptying and Affects the Post-Prandial Rise in Plasma Amino Acid Concentrations Following Protein Ingestion in Humans. Nutrients 2016, 8, 221. https://doi.org/10.3390/nu8040221

AMA Style

Holwerda AM, Lenaerts K, Bierau J, Van Loon LJC. Body Position Modulates Gastric Emptying and Affects the Post-Prandial Rise in Plasma Amino Acid Concentrations Following Protein Ingestion in Humans. Nutrients. 2016; 8(4):221. https://doi.org/10.3390/nu8040221

Chicago/Turabian Style

Holwerda, Andrew M., Kaatje Lenaerts, Jörgen Bierau, and Luc J.C. Van Loon 2016. "Body Position Modulates Gastric Emptying and Affects the Post-Prandial Rise in Plasma Amino Acid Concentrations Following Protein Ingestion in Humans" Nutrients 8, no. 4: 221. https://doi.org/10.3390/nu8040221

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