Next Article in Journal
The Effect of Selenium Supplementation on Glucose Homeostasis and the Expression of Genes Related to Glucose Metabolism
Previous Article in Journal
Anti-Inflammatory Effects of Vitamin D on Human Immune Cells in the Context of Bacterial Infection
Open AccessArticle

Anti-Fatigue Effects of Small Molecule Oligopeptides Isolated from Panax ginseng C. A. Meyer in Mice

by Lei Bao 1,2, Xiaxia Cai 2,3, Junbo Wang 2, Yuan Zhang 2, Bin Sun 2 and Yong Li 2,*
Department of Nutrition and Dietetics, Peking University International Hospital, Beijing 102206, China
Department of Nutrition and Food Hygiene, School of Public Health, Peking University, Beijing 100191, China
School of Public Health, Beijing Key Laboratory of Environmental Toxicology, Capital Medical University, Beijing 100069, China
Author to whom correspondence should be addressed.
Nutrients 2016, 8(12), 807;
Received: 8 October 2016 / Revised: 29 November 2016 / Accepted: 2 December 2016 / Published: 13 December 2016
Panax ginseng C. A. Meyer (ginseng) is an edible and medicinal Chinese herb, which is often used in Asian countries for physical fitness. Ginseng is reported to have a wide range of biological activity and pharmaceutical properties. There were more studies on ginsenosides and polysaccharides, but fewer studies on ginseng oligopeptides (GOP), which are small molecule oligopeptides isolated from ginseng. The present study was designed to evaluate the anti-fatigue effects of GOP in mice and explore the possible underlying mechanism. Mice were randomly divided into four experimental sets for the detection of different indicators. Each set of mice were then divided into four groups. The control group was administered distilled water, and three GOP intervention groups were administered 125, 250, and 500 mg/kg of body weight, respectively, of GOP by gavage each day. After 30 days of GOP treatment, it was observed that GOP could significantly increase the forced swimming time, enhance lactate dehydrogenase (LDH) activity and hepatic glycogen levels, and retard the accumulation of serum urea nitrogen (SUN) and blood lactic acid (BLA) in mice. GOP also markedly ameliorated fatigue-induced alterations of inoxidative stress biomarkers and antioxidant enzymes. Notably, GOP increased the mRNA expression of mitochondrial biogenesis factors and mitochondrial DNA content in skeletal muscles of mice. These results suggest that GOP possess anti-fatigue effects, which may be attributed to the inhibition of oxidative stress and the improvement of mitochondrial function in skeletal muscles. GOP could be a novel natural agent for relieving exercise fatigue. View Full-Text
Keywords: ginseng oligopeptides; anti-fatigue; forced swimming test ginseng oligopeptides; anti-fatigue; forced swimming test
Show Figures

Figure 1

MDPI and ACS Style

Bao, L.; Cai, X.; Wang, J.; Zhang, Y.; Sun, B.; Li, Y. Anti-Fatigue Effects of Small Molecule Oligopeptides Isolated from Panax ginseng C. A. Meyer in Mice. Nutrients 2016, 8, 807.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Back to TopTop