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Open AccessArticle

Nutrient Transporter Expression in the Jejunum in Relation to Body Mass Index in Patients Undergoing Bariatric Surgery

1
Obesity Institute, Geisinger Health System, 100 N Academy Ave, Danville, PA 17822, USA
2
Department of Cell Biology and Biochemistry, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA
3
Medicine Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
4
Surgery, Geisinger Health System, 100 N Academy Ave, Danville, PA 17822, USA
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Department of Medical Genetics and Molecular Biochemistry, Lewis Katz School of Medicine, Temple University, Medicine Education & Research Building 3500 N. Broad St., Philadelphia, PA 19140, USA
6
Internal Medicine, Geisinger Health System, 100 N Academy Ave, Danville, PA 17822, USA
*
Author to whom correspondence should be addressed.
Nutrients 2016, 8(11), 683; https://doi.org/10.3390/nu8110683
Received: 16 August 2016 / Revised: 11 October 2016 / Accepted: 26 October 2016 / Published: 29 October 2016
Nutrient tranters (NT) facilitate nutrient absorption and contribute to the regulation of circulating nutrients. In this cross-sectional study, we determined the associations between the level of obesity; mRNA abundance for NTs; and serum concentrations of amino acids, short-chain fatty acids, and glucose in patients with morbid obesity undergoing a Roux-en-Y gastric bypass. Proximal jejunal samples were obtained at the time of surgery from 42 patients (90% female, age = 42.6 ± 11.9 years, pre-operative body mass index (BMI) = 55.5 ± 11.3 kg/m2) undergoing a Roux-en-Y gastric bypass. RNA was extracted from the jejunal mucosa and quantitative real-time–PCR was performed for the NTs studied. BMI negatively correlated with jejunal mRNA abundance of the amino acid NTs TauT (r = −0.625, p < 0.0001), ASCT2 (r = −0.320, p = 0.039), LAT1 (r = −0.304, p = 0.05). BMI positively correlated with jejunal mRNA abundance of the lactate/short-chain fatty acid NT SMCT1 (r = 0.543, p = 0.0002). Serum concentrations of the short-chain fatty acids, butyric, valeric, and isocaproic acid correlated positively with BMI (n = 30) (r = 0.45, r = 0.44, r = 0.36, p ≤ 0.05; respectively). Lower jejunal mRNA abundance for the amino acid NTs TauT, ASCT2, and LAT1 could protect against further obesity-related elevations in circulating amino acids. The positive correlation between BMI and the jejunal mRNA abundance of the high-affinity short-chain fatty acid/monocarboxylate transporter SMCT1 is intriguing and requires further investigation. View Full-Text
Keywords: obesity; morbid obesity; nutrient transporters; nutrient absorption; gastrointestinal tract obesity; morbid obesity; nutrient transporters; nutrient absorption; gastrointestinal tract
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Irving, B.A.; Wood, G.C.; Bennotti, P.N.; Babu, E.; Deshpande, A.; Lent, M.R.; Petrick, A.; Gabrielsen, J.; Strodel, W.; Gerhard, G.S.; Still, C.D.; Ganapathy, V.; Rolston, D.D.K. Nutrient Transporter Expression in the Jejunum in Relation to Body Mass Index in Patients Undergoing Bariatric Surgery. Nutrients 2016, 8, 683.

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