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Nutrients 2015, 7(4), 3038-3053;

Ginseng Berry Extract Supplementation Improves Age-Related Decline of Insulin Signaling in Mice

College of Pharmacy and Gachon Institute of Pharmaceutical Science, Gachon University, Incheon 406-840, Korea
Lee Gil Ya Cancer and Diabetes Institute, Gachon University, Incheon 406-840, Korea
Center, Amorepacific Corporation, Gyeonggi-do 446-729, Korea
Gachon Medical Research Institute, Gil Hospital, Incheon 405-760, Korea
Author to whom correspondence should be addressed.
Received: 4 March 2015 / Revised: 23 March 2015 / Accepted: 10 April 2015 / Published: 22 April 2015
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The aim of this study was to evaluate the effects of ginseng berry extract on insulin sensitivity and associated molecular mechanisms in aged mice. C57BL/6 mice (15 months old) were maintained on a regular diet (CON) or a regular diet supplemented with 0.05% ginseng berry extract (GBD) for 24 or 32 weeks. GBD-fed mice showed significantly lower serum insulin levels (p = 0.016) and insulin resistance scores (HOMA-IR) (p = 0.012), suggesting that GBD improved insulin sensitivity. Pancreatic islet hypertrophy was also ameliorated in GBD-fed mice (p = 0.007). Protein levels of tyrosine phosphorylated insulin receptor substrate (IRS)-1 (p = 0.047), and protein kinase B (AKT) (p = 0.037), were up-regulated in the muscle of insulin-injected GBD-fed mice compared with CON-fed mice. The expressions of forkhead box protein O1 (FOXO1) (p = 0.036) and peroxisome proliferator-activated receptor gamma (PPARγ) (p = 0.032), which are known as aging- and insulin resistance-related genes, were also increased in the muscle of GBD-fed mice. We conclude that ginseng berry extract consumption might increase activation of IRS-1 and AKT, contributing to the improvement of insulin sensitivity in aged mice. View Full-Text
Keywords: ginseng berry; aging; insulin sensitivity ginseng berry; aging; insulin sensitivity

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Seo, E.; Kim, S.; Lee, S.J.; Oh, B.-C.; Jun, H.-S. Ginseng Berry Extract Supplementation Improves Age-Related Decline of Insulin Signaling in Mice. Nutrients 2015, 7, 3038-3053.

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