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Open AccessArticle

Ginseng Berry Extract Supplementation Improves Age-Related Decline of Insulin Signaling in Mice

College of Pharmacy and Gachon Institute of Pharmaceutical Science, Gachon University, Incheon 406-840, Korea
Lee Gil Ya Cancer and Diabetes Institute, Gachon University, Incheon 406-840, Korea
Center, Amorepacific Corporation, Gyeonggi-do 446-729, Korea
Gachon Medical Research Institute, Gil Hospital, Incheon 405-760, Korea
Author to whom correspondence should be addressed.
Nutrients 2015, 7(4), 3038-3053;
Received: 4 March 2015 / Revised: 23 March 2015 / Accepted: 10 April 2015 / Published: 22 April 2015
The aim of this study was to evaluate the effects of ginseng berry extract on insulin sensitivity and associated molecular mechanisms in aged mice. C57BL/6 mice (15 months old) were maintained on a regular diet (CON) or a regular diet supplemented with 0.05% ginseng berry extract (GBD) for 24 or 32 weeks. GBD-fed mice showed significantly lower serum insulin levels (p = 0.016) and insulin resistance scores (HOMA-IR) (p = 0.012), suggesting that GBD improved insulin sensitivity. Pancreatic islet hypertrophy was also ameliorated in GBD-fed mice (p = 0.007). Protein levels of tyrosine phosphorylated insulin receptor substrate (IRS)-1 (p = 0.047), and protein kinase B (AKT) (p = 0.037), were up-regulated in the muscle of insulin-injected GBD-fed mice compared with CON-fed mice. The expressions of forkhead box protein O1 (FOXO1) (p = 0.036) and peroxisome proliferator-activated receptor gamma (PPARγ) (p = 0.032), which are known as aging- and insulin resistance-related genes, were also increased in the muscle of GBD-fed mice. We conclude that ginseng berry extract consumption might increase activation of IRS-1 and AKT, contributing to the improvement of insulin sensitivity in aged mice. View Full-Text
Keywords: ginseng berry; aging; insulin sensitivity ginseng berry; aging; insulin sensitivity
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Seo, E.; Kim, S.; Lee, S.J.; Oh, B.-C.; Jun, H.-S. Ginseng Berry Extract Supplementation Improves Age-Related Decline of Insulin Signaling in Mice. Nutrients 2015, 7, 3038-3053.

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