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Acknowledgement to Reviewers of Nutrients in 2013
Open AccessArticle

The Effect of Multivitamin/Mineral Supplements on Age-Related Cataracts: A Systematic Review and Meta-Analysis

Department of Ophthalmology, No. 181 Hospital of the PLA, No.1 Xinqiaoyuan Road, Guilin 541002, China
Department of Ophthalmology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, No. 1665 Kongjiang Road, Shanghai 200092, China
Author to whom correspondence should be addressed.
Nutrients 2014, 6(3), 931-949;
Received: 30 November 2013 / Revised: 15 January 2014 / Accepted: 24 January 2014 / Published: 28 February 2014
Antioxidant vitamins supplements have been suggested as a strategy to decrease the risk of age-related cataract development. However, the results from observational studies and interventional trials of associations between antioxidant vitamins A, C, and E and cataract development have been inconsistent. We aim to evaluate the effectiveness of multivitamin/mineral supplements for decreasing the risk of age-related cataracts by conducting a systematic review and meta-analysis. In September 2013, we searched multiple databases to identify relevant studies including both cohort studies and randomized controlled trials (RCTs). A random-effects model was used to calculate the pooled relative risks (RR) with a 95% confidence interval (CI). Twelve prospective cohort studies and two RCTs were included. Pooled results from the cohort studies indicated that multivitamin/mineral supplements have a significant beneficial effect in decreasing the risk of nuclear cataracts (RR: 0.73; 95% CI: 0.64–0.82), cortical cataracts (RR: 0.81; 95% CI: 0.68–0.94), and any cataracts (RR: 0.66; 95% CI: 0.39–0.93). In addition, there were no decreases in the risk of posterior capsular cataracts (RR: 0.96; 95% CI: 0.72–1.20) or cataract surgery (RR: 1.00; 95% CI: 0.92–1.08). The two RCTs demonstrated that multivitamin/mineral supplements could decrease the risk of nuclear cataracts. There is sufficient evidence to support the role of dietary multivitamin/mineral supplements for the decreasing the risk of age-related cataracts. View Full-Text
Keywords: dietary supplements; cataract; vitamins; minerals; meta-analysis dietary supplements; cataract; vitamins; minerals; meta-analysis
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Zhao, L.-Q.; Li, L.-M.; Zhu, H.; The Epidemiological Evidence-Based Eye Disease Study Research Group. The Effect of Multivitamin/Mineral Supplements on Age-Related Cataracts: A Systematic Review and Meta-Analysis. Nutrients 2014, 6, 931-949.

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