Correlation between Olive Oil Intake and Gut Microbiota in Colorectal Cancer Prevention
Abstract
:1. Introduction
2. Quality of Olive Oils on the Market
3. Oil: Components and Features
4. Role of Olive Oil in Colorectal Cancer Prevention
5. Gut Microbiota and CRC Development
6. Role of Olive Oil on Microbiota
7. Ongoing Clinical Trials
8. Conclusions
Author Contributions
Funding
Conflicts of Interest
References
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Microorganisms Associated with CRC Increased Risk | Microorganisms Associated with CRC Prevention |
---|---|
Streptococcus bovis Bacteroides fragilis Fusobacterium nucleatum Enterococcus faecalis Escherichia coli Peptostreptococcus anaerobius Staphylococcus spp. Pseudomonas spp. Neisseria spp. Sphingomonas spp. Prevotella spp. | Akkermansia muciniphila Bifidobacterium spp. Firmicutes spp. Lactococcus lactis |
Name of Study and NCT Number | Phase | Study Arms | N° of Patients | Study Type | Status |
---|---|---|---|---|---|
Phase 3 Study of Enteral Nutrition Rich in Eicosapentaenoic Acid (EPA) in Patients Receiving Chemotherapy for Gastric Cancer or Colorectal Cancer NCT01048463 [27] | Phase 3 | Placebo Comparator: EN vs. Experimental: ENLDEPA (Nutriall+LDEPA+ Xelox) vs. Experimental: ENHDEPA (nutriall+HDEPA+ Xelox) | 90 | Interventional | Unknown status |
A Mediterranean Diet in Colon Cancer Prevention NCT00475722 [28] | Not Applicable | Active Comparator: 1 Healthy Eating vs. Experimental: 2 Mediterranean | 120 | Interventional | Completed |
The Effects of EPA on Biomarkers of Growth and Vascularity in Human Colorectal Cancer Liver Metastases (The EPA for Metastasis Trial) NCT01070355 [29] | Phase 2 | Placebo Comparator: Placebo vs Active. Comparator: EPA free fatty acid | 88 | Interventional | Completed |
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Memmola, R.; Petrillo, A.; Di Lorenzo, S.; Altuna, S.C.; Habeeb, B.S.; Soggiu, A.; Bonizzi, L.; Garrone, O.; Ghidini, M. Correlation between Olive Oil Intake and Gut Microbiota in Colorectal Cancer Prevention. Nutrients 2022, 14, 3749. https://doi.org/10.3390/nu14183749
Memmola R, Petrillo A, Di Lorenzo S, Altuna SC, Habeeb BS, Soggiu A, Bonizzi L, Garrone O, Ghidini M. Correlation between Olive Oil Intake and Gut Microbiota in Colorectal Cancer Prevention. Nutrients. 2022; 14(18):3749. https://doi.org/10.3390/nu14183749
Chicago/Turabian StyleMemmola, Raffaella, Angelica Petrillo, Sara Di Lorenzo, Sara C. Altuna, Baker Shalal Habeeb, Alessio Soggiu, Luigi Bonizzi, Ornella Garrone, and Michele Ghidini. 2022. "Correlation between Olive Oil Intake and Gut Microbiota in Colorectal Cancer Prevention" Nutrients 14, no. 18: 3749. https://doi.org/10.3390/nu14183749