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Review

The Efficacy of Vitamin D Supplementation in the Treatment of Fibromyalgia Syndrome and Chronic Musculoskeletal Pain

1
Department of Human Sciences and Promotion of the Quality of Life, San Raffaele Open University, 00166 Rome, Italy
2
Laboratory of Cardiovascular Endocrinology, San Raffaele Research Institute, IRCCS San Raffaele Roma, Via di Val Cannuta, 247, 00166 Rome, Italy
3
Independent Researcher, Via Venezuela 66, 98121 Messina, Italy
4
PhD Program in Endocrinological Sciences, Department of Experimental Medicine, University of Rome “La Sapienza”, Piazzale Aldo Moro, 5, 00185 Rome, Italy
*
Author to whom correspondence should be addressed.
Academic Editors: Gregory C. Bogdanis and Christoforos D. Giannaki
Nutrients 2022, 14(15), 3010; https://doi.org/10.3390/nu14153010
Received: 19 June 2022 / Revised: 13 July 2022 / Accepted: 21 July 2022 / Published: 22 July 2022
(This article belongs to the Special Issue Dietary Supplements and Musculoskeletal Health and Function)
Fibromyalgia syndrome (FMS) and chronic widespread musculoskeletal pain (CMP) are diffuse suffering syndromes that interfere with normal activities. Controversy exists over the role of vitamin D in the treatment of these diseases. We carried out a systematic literature review of randomized controlled trials (RCT) to establish whether vitamin D (25OHD) deficiency is more prevalent in CMP patients and to assess the effects of vitamin D supplementation in pain management in these individuals. We searched PubMed, Physiotherapy Evidence Database (PEDro), and the Cochrane Central Register of Controlled Trials (CENTRAL) for RCTs published in English from 1 January 1990 to 10 July 2022. A total of 434 studies were accessed, of which 14 satisfied the eligibility criteria. In our review three studies, of which two had the best-quality evidence, a correlation between diffuse muscle pain and 25OHD deficiency was confirmed. Six studies, of which four had the best-quality evidence, demonstrated that appropriate supplementation may have beneficial effects in patients with established blood 25OHD deficiency. Eight studies, of which six had the best-quality evidence, demonstrated that 25OHD supplementation results in pain reduction. Our results suggest a possible role of vitamin D supplementation in alleviating the pain associated with FMS and CMP, especially in vitamin D-deficient individuals. View Full-Text
Keywords: vitamin D; fibromyalgia; widespread pain; hypovitaminosis; systematic review vitamin D; fibromyalgia; widespread pain; hypovitaminosis; systematic review
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MDPI and ACS Style

Lombardo, M.; Feraco, A.; Ottaviani, M.; Rizzo, G.; Camajani, E.; Caprio, M.; Armani, A. The Efficacy of Vitamin D Supplementation in the Treatment of Fibromyalgia Syndrome and Chronic Musculoskeletal Pain. Nutrients 2022, 14, 3010. https://doi.org/10.3390/nu14153010

AMA Style

Lombardo M, Feraco A, Ottaviani M, Rizzo G, Camajani E, Caprio M, Armani A. The Efficacy of Vitamin D Supplementation in the Treatment of Fibromyalgia Syndrome and Chronic Musculoskeletal Pain. Nutrients. 2022; 14(15):3010. https://doi.org/10.3390/nu14153010

Chicago/Turabian Style

Lombardo, Mauro, Alessandra Feraco, Morena Ottaviani, Gianluca Rizzo, Elisabetta Camajani, Massimiliano Caprio, and Andrea Armani. 2022. "The Efficacy of Vitamin D Supplementation in the Treatment of Fibromyalgia Syndrome and Chronic Musculoskeletal Pain" Nutrients 14, no. 15: 3010. https://doi.org/10.3390/nu14153010

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