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Article

Matcha Green Tea Alleviates Non-Alcoholic Fatty Liver Disease in High-Fat Diet-Induced Obese Mice by Regulating Lipid Metabolism and Inflammatory Responses

Tea Research Institute, Zhejiang University, Hangzhou 310058, China
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Author to whom correspondence should be addressed.
Academic Editor: Henricus A. M. Mutsaers
Nutrients 2021, 13(6), 1950; https://doi.org/10.3390/nu13061950
Received: 14 May 2021 / Revised: 1 June 2021 / Accepted: 3 June 2021 / Published: 6 June 2021
(This article belongs to the Special Issue Diet to Treat Fatty Liver Disease)
Lately, matcha green tea has gained popularity as a beverage and food additive. It has proved to be effective in preventing obesity and related metabolic syndromes. However, the underlying mechanisms of its control effects against non-alcoholic fatty liver disease (NAFLD) are complicated and remain elusive. In the present study, we performed an in vivo experiment using male C57BL/6 mice fed with a high-fat diet and simultaneously treated with matcha for six weeks. Serum biochemical parameters, histological changes, lipid accumulation, inflammatory cytokines, and relevant indicators were examined. Dietary supplementation of matcha effectively prevented excessive accumulation of visceral and hepatic lipid, elevated blood glucose, dyslipidemia, abnormal liver function, and steatosis hepatitis. RNA sequencing analyses of differentially expressed genes in liver samples indicated that matcha treatment decreased the activity of lipid droplet-associated proteins and increased the activity of cytochrome P450 enzymes, suggesting improved metabolic capacity and liver function. The current study provided evidence for new dietary strategies based on matcha supplementation to ameliorate lipotoxicity-induced obesity and NALFD. View Full-Text
Keywords: matcha green tea; nonalcoholic fatty liver disease; nonalcoholic steatohepatitis; fatty toxicity; lipid droplets-associated proteins; cytochrome P450 matcha green tea; nonalcoholic fatty liver disease; nonalcoholic steatohepatitis; fatty toxicity; lipid droplets-associated proteins; cytochrome P450
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MDPI and ACS Style

Zhou, J.; Yu, Y.; Ding, L.; Xu, P.; Wang, Y. Matcha Green Tea Alleviates Non-Alcoholic Fatty Liver Disease in High-Fat Diet-Induced Obese Mice by Regulating Lipid Metabolism and Inflammatory Responses. Nutrients 2021, 13, 1950. https://doi.org/10.3390/nu13061950

AMA Style

Zhou J, Yu Y, Ding L, Xu P, Wang Y. Matcha Green Tea Alleviates Non-Alcoholic Fatty Liver Disease in High-Fat Diet-Induced Obese Mice by Regulating Lipid Metabolism and Inflammatory Responses. Nutrients. 2021; 13(6):1950. https://doi.org/10.3390/nu13061950

Chicago/Turabian Style

Zhou, Jihong, Yueer Yu, Lejia Ding, Ping Xu, and Yuefei Wang. 2021. "Matcha Green Tea Alleviates Non-Alcoholic Fatty Liver Disease in High-Fat Diet-Induced Obese Mice by Regulating Lipid Metabolism and Inflammatory Responses" Nutrients 13, no. 6: 1950. https://doi.org/10.3390/nu13061950

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