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Decreased Efficiency of Very-Low-Density Lipoprotein Lipolysis Is Linked to Both Hypertriglyceridemia and Hypercholesterolemia, but It Can Be Counteracted by High-Density Lipoprotein
Review

Triglyceride-Rich Lipoproteins and Their Remnants as Silent Promoters of Atherosclerotic Cardiovascular Disease and Other Metabolic Disorders: A Review

1
Internal Medicine Department, ”Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iași, Romania
2
Cardiology Department, Institute of Cardiovascular Diseases Prof. Dr. George I.M. Georgescu, 700503 Iași, Romania
*
Author to whom correspondence should be addressed.
Academic Editors: John Mamo, Ryu Takechi and Virginie Lam
Nutrients 2021, 13(6), 1774; https://doi.org/10.3390/nu13061774
Received: 30 April 2021 / Revised: 18 May 2021 / Accepted: 20 May 2021 / Published: 22 May 2021
(This article belongs to the Special Issue The Role of Triglycerides and Triglyceride Metabolism in Human Health)
While targeting elevated serum levels of low-density lipoprotein cholesterol has been the mainstay of atherosclerosis prevention and treatment for decades, the evidence regarding the atherogenic role of hypertriglyceridemia is still controversial. Various epidemiological population-based studies on statin-treated subjects nominated triglycerides, triglyceride-rich lipoproteins (namely, chylomicrons and very-low-density lipoprotein particles), and their remnants as major determinants of the substantial residual cardiovascular risk. With the triglyceride-glucose index and triglyceride to high-density lipoprotein ratio emerging as surrogate indicators of peripheral artery disease and atherosclerotic cerebrovascular disease, one can conclude that further research addressing the intricate relationship between triglycerides and atherosclerosis is warranted. Therefore, this review aims to provide insight into the current clinical and epidemiological state of knowledge on the relationship between triglycerides and atherosclerotic cardiovascular disease. It also intends to highlight the connection between triglycerides and other metabolic disorders, including diabetes mellitus, and the potential benefits of triglyceride-lowering agents on cardiovascular outcomes and all-cause mortality. View Full-Text
Keywords: triglyceride; triglyceride-rich lipoproteins; atherosclerosis; metabolic disorders; cardiovascular outcomes triglyceride; triglyceride-rich lipoproteins; atherosclerosis; metabolic disorders; cardiovascular outcomes
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MDPI and ACS Style

Sascău, R.; Clement, A.; Radu, R.; Prisacariu, C.; Stătescu, C. Triglyceride-Rich Lipoproteins and Their Remnants as Silent Promoters of Atherosclerotic Cardiovascular Disease and Other Metabolic Disorders: A Review. Nutrients 2021, 13, 1774. https://doi.org/10.3390/nu13061774

AMA Style

Sascău R, Clement A, Radu R, Prisacariu C, Stătescu C. Triglyceride-Rich Lipoproteins and Their Remnants as Silent Promoters of Atherosclerotic Cardiovascular Disease and Other Metabolic Disorders: A Review. Nutrients. 2021; 13(6):1774. https://doi.org/10.3390/nu13061774

Chicago/Turabian Style

Sascău, Radu, Alexandra Clement, Rodica Radu, Cristina Prisacariu, and Cristian Stătescu. 2021. "Triglyceride-Rich Lipoproteins and Their Remnants as Silent Promoters of Atherosclerotic Cardiovascular Disease and Other Metabolic Disorders: A Review" Nutrients 13, no. 6: 1774. https://doi.org/10.3390/nu13061774

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