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Review

Relation between Vitamin D and COVID-19 in Aged People: A Systematic Review

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Faculty of Medicine, University of the French West Indies, 97200 Fort-de-France, France
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Department of Clinical Research and Innovation, University Hospitals of Martinique, Pierre Zobda-Quitman Hospital, 97261 Fort-de-France, France
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Department of Geriatrics, University Hospitals of Rennes, 35000 Rennes, France
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Department of Infectious Diseases, University Hospitals of Reims, 51100 Reims, France
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Department of Geriatrics, General Hospital of Valenciennes, 59300 Valenciennes, France
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Department of Clinical Research and Innovation, University Hospitals of Reims, 51100 Reims, France
*
Authors to whom correspondence should be addressed.
Academic Editor: Michael F. Holick
Nutrients 2021, 13(4), 1339; https://doi.org/10.3390/nu13041339
Received: 2 March 2021 / Revised: 8 April 2021 / Accepted: 15 April 2021 / Published: 17 April 2021
Background: Vitamin D has diverse and extensive effects on the immune system, including activating innate immunity and reducing the overactive adaptive immune response. A systematic review was performed to identify and synthesize the best available evidence on the association between vitamin D level and risk of COVID-19, adverse outcomes and possible benefits of supplementation in aged 60 years or over. Methods: A literature search was performed in PubMed© and Scopus© for all publications from inception published before 15 March 2021. Studies reporting data from aged patients on vitamin D use and COVID-19 were included. Basic science articles, editorials and correspondence were excluded. Publication year, study design and setting, characteristics of the study population were extracted. This study is registered with PROSPERO, under the number CRD42020223993. Results: In total, 707 studies were identified, of which 11 observational studies were included in the final review. Four studies compared vitamin D-supplemented COVID-19 patients to non-supplemented patients, and seven compared patients with vitamin D deficiency to patients without deficiency. In all four studies, patients with vitamin D supplementation had better rates of primary clinical outcomes (death, the severity of the disease, oxygen therapy requirement…). In studies comparing patients with vitamin D deficiency and patients without vitamin D deficiency, those without vitamin D deficiency had better primary clinical outcomes (death rate, the severity of the disease, oxygen therapy requirement, invasive mechanical ventilation need…). Conclusion: This systematic review seems to support an association between vitamin D deficiency and the risk of COVID-19 in aged people. In addition, vitamin D deficiency appears to expose these subjects to a greater risk of adverse outcomes. Because of its simplicity of administration, and the rarity of side effects, including vitamin D in preventive strategies for certain viral diseases, it appears to be an attractive option. View Full-Text
Keywords: vitamin D; COVID-19; aged people vitamin D; COVID-19; aged people
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MDPI and ACS Style

Dramé, M.; Cofais, C.; Hentzien, M.; Proye, E.; Coulibaly, P.S.; Demoustier-Tampère, D.; Destailleur, M.-H.; Lotin, M.; Cantagrit, E.; Cebille, A.; Desprez, A.; Blondiau, F.; Kanagaratnam, L.; Godaert, L. Relation between Vitamin D and COVID-19 in Aged People: A Systematic Review. Nutrients 2021, 13, 1339. https://doi.org/10.3390/nu13041339

AMA Style

Dramé M, Cofais C, Hentzien M, Proye E, Coulibaly PS, Demoustier-Tampère D, Destailleur M-H, Lotin M, Cantagrit E, Cebille A, Desprez A, Blondiau F, Kanagaratnam L, Godaert L. Relation between Vitamin D and COVID-19 in Aged People: A Systematic Review. Nutrients. 2021; 13(4):1339. https://doi.org/10.3390/nu13041339

Chicago/Turabian Style

Dramé, Moustapha, Cécilia Cofais, Maxime Hentzien, Emeline Proye, Pécory S. Coulibaly, David Demoustier-Tampère, Marc-Henri Destailleur, Maxime Lotin, Eléonore Cantagrit, Agnès Cebille, Anne Desprez, Fanny Blondiau, Lukshe Kanagaratnam, and Lidvine Godaert. 2021. "Relation between Vitamin D and COVID-19 in Aged People: A Systematic Review" Nutrients 13, no. 4: 1339. https://doi.org/10.3390/nu13041339

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