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Article

Short-Term Calorie Restriction Maintains Plasma Insulin Concentrations along with a Reduction in Hepatic Insulin-Degrading Enzyme Levels in db/db Mice

1
Bioscience and Technology Program, Department of Engineering Science, University of Electro-Communications, 1-5-1 Chofugaoka, Chofu, Tokyo 182-8585, Japan
2
Japan Society for the Promotion of Science (JSPS), Kojimachi, Chiyoda-ku, Tokyo 102-0083, Japan
*
Author to whom correspondence should be addressed.
Academic Editor: Sara Baldassano
Nutrients 2021, 13(4), 1190; https://doi.org/10.3390/nu13041190
Received: 8 March 2021 / Revised: 26 March 2021 / Accepted: 29 March 2021 / Published: 3 April 2021
(This article belongs to the Section Nutrition and Metabolism)
Maintaining blood insulin levels is important for patients with diabetes because insulin secretion capacity declines with the development of the disease. Calorie restriction (CR) is effective for the improvement of glucose tolerance, but it is not clear whether CR can maintain insulin levels in the late stage of diabetes. We examined the effect of CR on whole-body glucose tolerance and fasting blood insulin concentrations in the late stage of diabetes. Male db/db mice were subjected to either a standard laboratory diet ad libitum for 3 weeks (dbdb group) or 40% CR (dbdb+CR group). CR significantly decreased body mass and epididymal fat weight. Glucose tolerance and fasting glucose levels were significantly improved with 3-week CR. Fasting insulin concentrations were decreased in the dbdb group but were maintained in the dbdb+CR group. CR significantly reduced insulin-degrading enzyme (IDE) levels in the liver, and hepatic IDE levels were significantly positively and negatively correlated with plasma glucose concentrations (area under the curve) after glucose administration and after fasting insulin concentrations, respectively. Therefore, 3-week CR maintained blood insulin levels and improved glucose tolerance with decreased hepatic IDE levels in an animal model of late-stage diabetes. View Full-Text
Keywords: calorie restriction; glucose transporter 4 (GLUT-4); insulin-degrading enzyme (IDE); diabetes calorie restriction; glucose transporter 4 (GLUT-4); insulin-degrading enzyme (IDE); diabetes
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MDPI and ACS Style

Nonaka, Y.; Takeda, R.; Kano, Y.; Hoshino, D. Short-Term Calorie Restriction Maintains Plasma Insulin Concentrations along with a Reduction in Hepatic Insulin-Degrading Enzyme Levels in db/db Mice. Nutrients 2021, 13, 1190. https://doi.org/10.3390/nu13041190

AMA Style

Nonaka Y, Takeda R, Kano Y, Hoshino D. Short-Term Calorie Restriction Maintains Plasma Insulin Concentrations along with a Reduction in Hepatic Insulin-Degrading Enzyme Levels in db/db Mice. Nutrients. 2021; 13(4):1190. https://doi.org/10.3390/nu13041190

Chicago/Turabian Style

Nonaka, Yudai, Reo Takeda, Yutaka Kano, and Daisuke Hoshino. 2021. "Short-Term Calorie Restriction Maintains Plasma Insulin Concentrations along with a Reduction in Hepatic Insulin-Degrading Enzyme Levels in db/db Mice" Nutrients 13, no. 4: 1190. https://doi.org/10.3390/nu13041190

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