Next Article in Journal
Micronutrients and Markers of Oxidative Stress and Inflammation Related to Cardiometabolic Health: Results from the EHES-LUX Study
Previous Article in Journal
Reducing Iron Content in Infant Formula from 8 to 2 mg/L Does Not Increase the Risk of Iron Deficiency at 4 or 6 Months of Age: A Randomized Controlled Trial
Article

Effect of Milk-Based Infant Formula Fortified with PUFAs on Lipid Profile, Growth and Micronutrient Status of Young Children: A Randomized Double-Blind Clinical Trial

1
Centro de Investigación en Nutrición y Salud, Instituto Nacional de Salud Pública, Cuernavaca 62100, Mexico
2
Centro de Investigación en Salud Poblacional, Instituto Nacional de Salud Pública, Cuernavaca 62100, Mexico
3
Centro de Investigación en Evaluación y Encuestas, Instituto Nacional de Salud Pública, Cuernavaca 62100, Mexico
4
Unidad de Investigación Médica en Nutrición, Hospital de Pediatría, Centro Médico Nacional Siglo XXI, IMSS, Ciudad de México 06720, Mexico
*
Author to whom correspondence should be addressed.
Nutrients 2021, 13(1), 4; https://doi.org/10.3390/nu13010004
Received: 6 November 2020 / Revised: 11 December 2020 / Accepted: 18 December 2020 / Published: 22 December 2020
(This article belongs to the Section Nutrition and Public Health)
Background: Polyunsaturated fatty acids (PUFAs) are essential to child growth and development. Objective: To assess the effect of PUFAs-fortified infant formula on lipid profile, growth and micronutrient status in children 12 to 30 months old. Methods: This study is a double-blind randomized controlled clinical trial. Two study groups were assessed: (a) milk-based infant formula with micronutrients and PUFAs (PUFAs) and (b) milk-based infant formula with micronutrients, no PUFAs added (Non-PUFAs). Children received prepared formula (240 mL) twice a day, according to the color-code assigned to each infant. Anthropometric measurements and venous blood samples were taken at each day-care center at baseline, and again after four months. Total serum lipid extraction was 0.5 mL. Samples were treated and modified by the Folch method and analyzed with gas chromatography. Results: Changes in serum lipid profile (expressed as % FA) between baseline and four months showed a statistically significant increase in docosahexaenoic acid (DHA) (0.22 vs. −0.07, p < 0.05) and Alpha-Linoleic acid (0.08 vs. 0.02, p < 0.05) in infants who consumed PUFAs-fortified formula compared to Non-PUFAs-fortified formula. Infants increased their length/height-for-age Z-score: median change for the PUFAs group was 0.16 (95% CI = 0.08, 0.28) and 0.23 (95% CI = 0.14, 0.33) for Non-PUFAs, with no differences between groups. Median folate level was significantly higher among the PUFAs group compared to Non-PUFAs: −0.87 (95% CI = −1.38, −0.44) and −3.83 (95% CI = −4.65, −3.03) respectively. Consumption of both supplements was adequate and stable during the intervention. Conclusion: A significant improvement was observed in the lipid profile of children who received the PUFAs-fortified milk-based formula. View Full-Text
Keywords: DHA; PUFAs; lipids; infant formula; micronutrients DHA; PUFAs; lipids; infant formula; micronutrients
Show Figures

Figure 1

MDPI and ACS Style

Rivera-Pasquel, M.; Flores-Aldana, M.; Parra-Cabrera, M.-S.; Quezada-Sánchez, A.D.; García-Guerra, A.; Maldonado-Hernández, J. Effect of Milk-Based Infant Formula Fortified with PUFAs on Lipid Profile, Growth and Micronutrient Status of Young Children: A Randomized Double-Blind Clinical Trial. Nutrients 2021, 13, 4. https://doi.org/10.3390/nu13010004

AMA Style

Rivera-Pasquel M, Flores-Aldana M, Parra-Cabrera M-S, Quezada-Sánchez AD, García-Guerra A, Maldonado-Hernández J. Effect of Milk-Based Infant Formula Fortified with PUFAs on Lipid Profile, Growth and Micronutrient Status of Young Children: A Randomized Double-Blind Clinical Trial. Nutrients. 2021; 13(1):4. https://doi.org/10.3390/nu13010004

Chicago/Turabian Style

Rivera-Pasquel, Marta, Mario Flores-Aldana, María-Socorro Parra-Cabrera, Amado D. Quezada-Sánchez, Armando García-Guerra, and Jorge Maldonado-Hernández. 2021. "Effect of Milk-Based Infant Formula Fortified with PUFAs on Lipid Profile, Growth and Micronutrient Status of Young Children: A Randomized Double-Blind Clinical Trial" Nutrients 13, no. 1: 4. https://doi.org/10.3390/nu13010004

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop