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Article

Interaction between Metabolic Genetic Risk Score and Dietary Fatty Acid Intake on Central Obesity in a Ghanaian Population

1
Hugh Sinclair Unit of Human Nutrition, Department of Food and Nutritional Sciences, University of Reading, Reading RG6 6AP, UK
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Department of Clinical Nutrition, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah 21589, Saudi Arabia
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Department of Biochemistry and Biotechnology, College of Science, Kwame Nkrumah University of Science and Technology, Accra GH233, Ghana
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Hugh Sinclair Unit of Human Nutrition and Institute for Cardiovascular and Metabolic Research, University of Reading, Reading RG6 6AP, UK
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Faculty of Health and Social Care, University of Chester, Riverside Campus, Chester CH1 4BJ, UK
*
Authors to whom correspondence should be addressed.
Nutrients 2020, 12(7), 1906; https://doi.org/10.3390/nu12071906
Received: 3 April 2020 / Revised: 4 June 2020 / Accepted: 24 June 2020 / Published: 27 June 2020
(This article belongs to the Special Issue Nutrient Gene Interactions)
Obesity is a multifactorial condition arising from the interaction between genetic and lifestyle factors. We aimed to assess the impact of lifestyle and genetic factors on obesity-related traits in 302 healthy Ghanaian adults. Dietary intake and physical activity were assessed using a 3 day repeated 24 h dietary recall and global physical activity questionnaire, respectively. Twelve single nucleotide polymorphisms (SNPs) were used to construct 4-SNP, 8-SNP and 12-SNP genetic risk scores (GRSs). The 4-SNP GRS showed significant interactions with dietary fat intakes on waist circumference (WC) (Total fat, Pinteraction = 0.01; saturated fatty acids (SFA), Pinteraction = 0.02; polyunsaturated fatty acids (PUFA), Pinteraction = 0.01 and monounsaturated fatty acids (MUFA), Pinteraction = 0.01). Among individuals with higher intakes of total fat (>47 g/d), SFA (>14 g/d), PUFA (>16 g/d) and MUFA (>16 g/d), individuals with ≥3 risk alleles had a significantly higher WC compared to those with <3 risk alleles. This is the first study of its kind in this population, suggesting that a higher consumption of dietary fatty acid may have the potential to increase the genetic susceptibility of becoming centrally obese. These results support the general dietary recommendations to decrease the intakes of total fat and SFA, to reduce the risk of obesity, particularly in individuals with a higher genetic predisposition to central obesity. View Full-Text
Keywords: genetic risk score; obesity; Ghana; GONG; fat intake; gene–diet interaction genetic risk score; obesity; Ghana; GONG; fat intake; gene–diet interaction
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MDPI and ACS Style

Alsulami, S.; Nyakotey, D.A.; Dudek, K.; Bawah, A.-M.; Lovegrove, J.A.; Annan, R.A.; Ellahi, B.; Vimaleswaran, K.S. Interaction between Metabolic Genetic Risk Score and Dietary Fatty Acid Intake on Central Obesity in a Ghanaian Population. Nutrients 2020, 12, 1906. https://doi.org/10.3390/nu12071906

AMA Style

Alsulami S, Nyakotey DA, Dudek K, Bawah A-M, Lovegrove JA, Annan RA, Ellahi B, Vimaleswaran KS. Interaction between Metabolic Genetic Risk Score and Dietary Fatty Acid Intake on Central Obesity in a Ghanaian Population. Nutrients. 2020; 12(7):1906. https://doi.org/10.3390/nu12071906

Chicago/Turabian Style

Alsulami, Sooad, David A. Nyakotey, Kamila Dudek, Abdul-Malik Bawah, Julie A. Lovegrove, Reginald A. Annan, Basma Ellahi, and Karani S. Vimaleswaran. 2020. "Interaction between Metabolic Genetic Risk Score and Dietary Fatty Acid Intake on Central Obesity in a Ghanaian Population" Nutrients 12, no. 7: 1906. https://doi.org/10.3390/nu12071906

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