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The Influence of Lycopene, [6]-Gingerol, and Silymarin on the Apoptosis on U-118MG Glioblastoma Cells In Vitro Model

1
Centre for Innovative Research in Medical and Natural Sciences, Medical Faculty of University of Rzeszow, 1a Warzywna St., 35-310 Rzeszow, Poland
2
Department of Human Immunology, Medical Faculty of University of Rzeszow, 1a Warzywna St., 35-310 Rzeszow, Poland
*
Author to whom correspondence should be addressed.
Nutrients 2020, 12(1), 96; https://doi.org/10.3390/nu12010096
Received: 27 November 2019 / Accepted: 22 December 2019 / Published: 30 December 2019
Background: Lycopene, gingerol, and silymarin have a potential anticancer activity in many types of neoplasms. Healthy lifestyle and proper diet are associated with a reduced risk of cancer and other diseases. Increasingly, clinical research focuses on the mechanisms of action of natural compounds and their impact on the development of cancer. The aim of the present study was to determine the effect of lycopene, gingerol, and silymarin on apoptosis, mitochondrial potential and caspase-3/7 activity in the U118-MG cell line. Methods: Human glioblastoma cells were incubated with lycopene, [6]-gingerol, and silymarin for 24 and 48 h. Apoptosis was monitored using the Annexin V labelling, caspase-3/7 activity, and early hallmark of apoptosis were determined with mitochondrial membrane potential changes. Results: Our data showed a significant decrease in the viability glioblastoma cells U118-MG after 48 h treatment with lycopene, [6]-gingerol, and silymarin. Conclusions: Our data could confirm the stimulative effects of used compounds on apoptosis and changes in mitochondrial potential in a dose-dependent manner. View Full-Text
Keywords: glioblastoma multiforme; Annexin V; mitochondrial membrane potential changes; caspase-3/7; apoptosis glioblastoma multiforme; Annexin V; mitochondrial membrane potential changes; caspase-3/7; apoptosis
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MDPI and ACS Style

Czarnik-Kwaśniak, J.; Kwaśniak, K.; Kwasek, P.; Świerzowska, E.; Strojewska, A.; Tabarkiewicz, J. The Influence of Lycopene, [6]-Gingerol, and Silymarin on the Apoptosis on U-118MG Glioblastoma Cells In Vitro Model. Nutrients 2020, 12, 96. https://doi.org/10.3390/nu12010096

AMA Style

Czarnik-Kwaśniak J, Kwaśniak K, Kwasek P, Świerzowska E, Strojewska A, Tabarkiewicz J. The Influence of Lycopene, [6]-Gingerol, and Silymarin on the Apoptosis on U-118MG Glioblastoma Cells In Vitro Model. Nutrients. 2020; 12(1):96. https://doi.org/10.3390/nu12010096

Chicago/Turabian Style

Czarnik-Kwaśniak, Justyna, Konrad Kwaśniak, Paulina Kwasek, Elżbieta Świerzowska, Agata Strojewska, and Jacek Tabarkiewicz. 2020. "The Influence of Lycopene, [6]-Gingerol, and Silymarin on the Apoptosis on U-118MG Glioblastoma Cells In Vitro Model" Nutrients 12, no. 1: 96. https://doi.org/10.3390/nu12010096

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