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Association of Salivary Amylase (AMY1) Gene Copy Number with Obesity in Alabama Elementary School Children

1
Department of Nutrition, Dietetics, and Hospitality Management, Auburn University, Auburn, AL 36849, USA
2
Boshell Metabolic Diseases and Diabetes Program, Auburn University, Auburn, AL 36849, USA
3
Department of Pathobiology, College of Veterinary Medicine, Auburn University, Auburn, AL 36849, USA
*
Author to whom correspondence should be addressed.
Nutrients 2019, 11(6), 1379; https://doi.org/10.3390/nu11061379
Received: 20 May 2019 / Revised: 16 June 2019 / Accepted: 17 June 2019 / Published: 19 June 2019
Salivary amylase (AMY1) is the most abundant enzyme in human saliva, responsible for the hydrolysis of α-1,4 glycosidic linkages that aids in the digestion of starch. Recently studies have shown that the copy number of AMY1 is associated with obesity; however, the data varies with location. One-third of children are overweight/obese in Alabama. In this study, we aim to determine the relationship between the copy number of AMY1 gene and obesity measurements in children from Alabama. One hundred twenty-seven children aged between 6 to 10 years participated in this study. Anthropometric measurements were measured using WHO recommendations. Genomic DNA was extracted from saliva, and the copy number of the AMY1 gene was estimated by digital PCR. The association between AMY1 copy number and obesity measurements was analyzed by linear regression. The mean AMY1 copy number significantly decreased in overweight/obese (6.21 ± 1.48) compared to normal weight (7.97 ± 2.35) children. AMY1 copy number inversely associated with the obesity measurements. African Americans had a stronger association between low AMY1 copy number and obesity compared to white/European Americans. Our findings suggest that overweight/obese children have a low AMY1 copy number and the effect is more prominent in African Americans. View Full-Text
Keywords: salivary amylase; AMY1; childhood obesity; copy number variant salivary amylase; AMY1; childhood obesity; copy number variant
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MDPI and ACS Style

Venkatapoorna, C.M.K.; Ayine, P.; Parra, E.P.; Koenigs, T.; Phillips, M.; Babu, J.R.; Sandey, M.; Geetha, T. Association of Salivary Amylase (AMY1) Gene Copy Number with Obesity in Alabama Elementary School Children. Nutrients 2019, 11, 1379. https://doi.org/10.3390/nu11061379

AMA Style

Venkatapoorna CMK, Ayine P, Parra EP, Koenigs T, Phillips M, Babu JR, Sandey M, Geetha T. Association of Salivary Amylase (AMY1) Gene Copy Number with Obesity in Alabama Elementary School Children. Nutrients. 2019; 11(6):1379. https://doi.org/10.3390/nu11061379

Chicago/Turabian Style

Venkatapoorna, Chandra M.K., Priscilla Ayine, Emily P. Parra, Taylor Koenigs, Megan Phillips, Jeganathan R. Babu, Maninder Sandey, and Thangiah Geetha. 2019. "Association of Salivary Amylase (AMY1) Gene Copy Number with Obesity in Alabama Elementary School Children" Nutrients 11, no. 6: 1379. https://doi.org/10.3390/nu11061379

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