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Open AccessArticle

Intracellular Water Content in Lean Mass is Associated with Muscle Strength, Functional Capacity, and Frailty in Community-Dwelling Elderly Individuals. A Cross-Sectional Study

1
Research Unit, Consorci Sanitari del Maresme, 08304 Mataró (Barcelona), Spain
2
Intensive Care Unit, Consorci Sanitari del Maresme, 08304 Mataró (Barcelona), Spain
3
Pharmacy Department. Consorci Sanitari del Maresme, 08304 Mataró (Barcelona), Spain
4
Geriatric Department, Consorci Sanitari del Maresme, 08304 Mataró (Barcelona), Spain
*
Author to whom correspondence should be addressed.
Nutrients 2019, 11(3), 661; https://doi.org/10.3390/nu11030661
Received: 28 January 2019 / Revised: 6 March 2019 / Accepted: 14 March 2019 / Published: 19 March 2019
(This article belongs to the Special Issue Hydration and Health: Scientific Evidence and Recommendations)
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Abstract

High intracellular water (ICW) content has been associated with better functional performance and a lower frailty risk in elderly people. However, it is not clear if the protective effect of high ICW is due to greater muscle mass or better muscle quality and cell hydration. We aimed to assess the relationship between ICW content in lean mass (LM) and muscle strength, functional performance, frailty, and other clinical characteristics in elderly people. In an observational cross-sectional study of community-dwelling subjects aged ≥75 years, ICW and LM were estimated by bioelectrical impedance, and the ICW/LM ratio (mL/kg) calculated. Muscle strength was measured as hand grip, frailty status was assessed according to Fried criteria, and functional status was assessed by Barthel score. For 324 recruited subjects (mean age 80 years), mean (SD) ICW/LM ratio was 408 (29.3) mL/kg. The ICW/LM ratio was negatively correlated with age (rs = −0.249; p < 0.001). A higher ICW/LM ratio was associated with greater muscle strength, better functional capacity, and a lower frailty risk, even when adjusted by age, sex, nº of co-morbidities, and LM. ICW content in LM (including the muscle) may influence muscle strength, functional capacity and frailty. However, further studies are needed to confirm this hypothesis. View Full-Text
Keywords: cell hydration; intracellular water; aging; muscle strength; frailty; functional capacity cell hydration; intracellular water; aging; muscle strength; frailty; functional capacity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Serra-Prat, M.; Lorenzo, I.; Palomera, E.; Yébenes, J.C.; Campins, L.; Cabré, M. Intracellular Water Content in Lean Mass is Associated with Muscle Strength, Functional Capacity, and Frailty in Community-Dwelling Elderly Individuals. A Cross-Sectional Study. Nutrients 2019, 11, 661.

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