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Maternal Flavonoids Intake Reverts Depression-Like Behaviour in Rat Female Offspring

1
Centro de Investigación en Nutrición y Salud Pública, Facultad de Salud Pública y Nutrición, Universidad Autonoma de Nuevo Leon, 64460 Monterrey, Mexico
2
Nutrition Unit, Center for Research and Development in Health Sciences, Universidad Autonoma de Nuevo Leon, 64460 Monterrey, Mexico
3
Department of Biochemistry, Facultad de Ciencias Biologicas, Universidad Autonoma de Nuevo Leon, 66455 Monterrey, Mexico
4
Department of Biochemistry, Facultad de Medicina, Universidad Autonoma de Nuevo Leon, 64460 Monterrey, Mexico
5
Neurometabolism Unit, Center for Research and Development in Health Sciences, Universidad Autonoma de Nuevo Leon, 64460 Monterrey, Mexico
6
Reproductive Biology Department, Instituto Nacional de Ciencias Medicas y Nutrición Salvador Zubiran, 14080 Mexico City, Mexico
7
Department of Pharmacology, Facultad de Medicina, Universidad Autonoma de Nuevo Leon, 64460 Monterrey, Mexico
*
Author to whom correspondence should be addressed.
Nutrients 2019, 11(3), 572; https://doi.org/10.3390/nu11030572
Received: 13 February 2019 / Revised: 28 February 2019 / Accepted: 28 February 2019 / Published: 7 March 2019
(This article belongs to the Special Issue Phytochemicals in Health and Disease)
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Abstract

Maternal hypercaloric exposure during pregnancy and lactation is a risk factor for developing diseases associated with inflammation such as obesity, diabetes and, neurological diseases in the offspring. Neuroinflammation might modulate neuronal activation and flavonoids are dietary compounds that have been proven to exert anti-inflammatory properties. Thus, the aim of the present study is to evaluate the effect of maternal supplementation with flavonoids (kaempferol-3-O-glucoside and narirutin) on the prevention of depression-like behaviour in the female offspring of dams fed with an obesogenic diet during the perinatal period. Maternal programming was induced by high fat (HFD), high sugar (HSD), or cafeteria diets exposure and depressive like-behaviour, referred to as swimming, climbing, and immobility events, was evaluated around postnatal day 56–60 before and after 30 mg/kg i.p. imipramine administration in the female offspring groups. Central inflammation was analyzed by measuring the TANK binding kinase 1 (TBK1) expression. We found that the offspring of mothers exposed to HSD programming failed to show the expected antidepressant effect of imipramine. Also, imipramine injection, to the offspring of mothers exposed to cafeteria diet, displayed a pro-depressive like-behaviour phenotype. However, dietary supplementation with flavonoids reverted the depression-like behaviour in the female offspring. Finally, we found that HSD programming increases the TBK1 inflammatory protein marker in the hippocampus. Our data suggest that maternal HSD programming disrupts the antidepressant effect of imipramine whereas cafeteria diet exposure leads to depressive-like behaviour in female offspring, which is reverted by maternal flavonoid supplementation. View Full-Text
Keywords: depression; nutritional programming; kaempferol; narirutin; inflammation depression; nutritional programming; kaempferol; narirutin; inflammation
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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de la Garza, A.L.; Garza-Cuellar, M.A.; Silva-Hernandez, I.A.; Cardenas-Perez, R.E.; Reyes-Castro, L.A.; Zambrano, E.; Gonzalez-Hernandez, B.; Garza-Ocañas, L.; Fuentes-Mera, L.; Camacho, A. Maternal Flavonoids Intake Reverts Depression-Like Behaviour in Rat Female Offspring. Nutrients 2019, 11, 572.

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