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Open AccessArticle

A Plant-Based Meal Stimulates Incretin and Insulin Secretion More Than an Energy- and Macronutrient-Matched Standard Meal in Type 2 Diabetes: A Randomized Crossover Study

1
Institute for Clinical and Experimental Medicine, 14021 Prague, Czech Republic
2
Physicians Committee for Responsible Medicine, Washington, 5100 Wisconsin Ave, NW, Suite 400, Washington, DC 20016, USA
3
Metabolic Unit, CNR Institute of Neuroscience, 35127 Padua, Italy
4
Institute of Endocrinology, 11394 Prague, Czech Republic
*
Author to whom correspondence should be addressed.
Nutrients 2019, 11(3), 486; https://doi.org/10.3390/nu11030486
Received: 4 February 2019 / Revised: 20 February 2019 / Accepted: 21 February 2019 / Published: 26 February 2019
(This article belongs to the Special Issue Nutritional Therapy for Diabetes Mellitus)
Diminished postprandial secretion of incretins and insulin represents one of the key pathophysiological mechanisms behind type 2 diabetes (T2D). We tested the effects of two energy- and macronutrient-matched meals: A standard meat (M-meal) and a vegan (V-meal) on postprandial incretin and insulin secretion in participants with T2D. A randomized crossover design was used in 20 participants with T2D. Plasma concentrations of glucose, insulin, C-peptide, glucagon-like peptide-1 (GLP-1), amylin, and gastric inhibitory peptide (GIP) were determined at 0, 30, 60, 120, and 180 min. Beta-cell function was assessed with a mathematical model, using C-peptide deconvolution. Repeated-measures ANOVA was used for statistical analysis. Postprandial plasma glucose responses were similar after both test meals (p = 0.64). An increase in the stimulated secretion of insulin (by 30.5%; 95% CI 21.2 to 40.7%; p < 0.001), C-peptide (by 7.1%; 95% CI 4.1 to 9.9%; p < 0.001), and amylin (by 15.7%; 95% CI 11.8 to 19.7%; p < 0.001) was observed following consumption of the V-meal. An increase in stimulated secretion of GLP-1 (by 19.2%; 95% CI 12.4 to 26.7%; p < 0.001) and a decrease in GIP (by −9.4%; 95% CI −17.3 to −0.7%; p = 0.02) were observed after the V-meal. Several parameters of beta-cell function increased after the V-meal, particularly insulin secretion at a fixed glucose value 5 mmol/L, rate sensitivity, and the potentiation factor. Our results showed an increase in postprandial incretin and insulin secretion, after consumption of a V-meal, suggesting a therapeutic potential of plant-based meals for improving beta-cell function in T2D. View Full-Text
Keywords: beta-cell function; incretins; insulin resistance; nutrition; plant-based; type 2 diabetes beta-cell function; incretins; insulin resistance; nutrition; plant-based; type 2 diabetes
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MDPI and ACS Style

Kahleova, H.; Tura, A.; Klementova, M.; Thieme, L.; Haluzik, M.; Pavlovicova, R.; Hill, M.; Pelikanova, T. A Plant-Based Meal Stimulates Incretin and Insulin Secretion More Than an Energy- and Macronutrient-Matched Standard Meal in Type 2 Diabetes: A Randomized Crossover Study. Nutrients 2019, 11, 486. https://doi.org/10.3390/nu11030486

AMA Style

Kahleova H, Tura A, Klementova M, Thieme L, Haluzik M, Pavlovicova R, Hill M, Pelikanova T. A Plant-Based Meal Stimulates Incretin and Insulin Secretion More Than an Energy- and Macronutrient-Matched Standard Meal in Type 2 Diabetes: A Randomized Crossover Study. Nutrients. 2019; 11(3):486. https://doi.org/10.3390/nu11030486

Chicago/Turabian Style

Kahleova, Hana; Tura, Andrea; Klementova, Marta; Thieme, Lenka; Haluzik, Martin; Pavlovicova, Renata; Hill, Martin; Pelikanova, Terezie. 2019. "A Plant-Based Meal Stimulates Incretin and Insulin Secretion More Than an Energy- and Macronutrient-Matched Standard Meal in Type 2 Diabetes: A Randomized Crossover Study" Nutrients 11, no. 3: 486. https://doi.org/10.3390/nu11030486

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