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Vitamin K in Chronic Kidney Disease

Renal Division, Department of Health Sciences, University of Milan, 20142 Milan, Italy
Renal Research Laboratory, Department of Nephrology, Dialysis and Renal Transplant, Fondazione IRCCS Ca’ Granda, Ospedale Maggiore Policlinico & Fondazione D’Amico per la Ricerca sulle Malattie Renali, 20122 Milan, Italy
Department of Medicine, Division of Nephrology, Massachusetts General Hospital, Boston, MA 02114, USA
Author to whom correspondence should be addressed.
Nutrients 2019, 11(1), 168;
Received: 16 November 2018 / Revised: 13 December 2018 / Accepted: 11 January 2019 / Published: 14 January 2019
Vitamin K is a composite term referring to a group of fat-soluble vitamins that function as a cofactor for the enzyme γ-glutamyl carboxylase (GGCX), which activates a number of vitamin K-dependent proteins (VKDPs) involved in haemostasis and vascular and bone health. Accumulating evidence demonstrates that chronic kidney disease (CKD) patients suffer from subclinical vitamin K deficiency, suggesting that this represents a population at risk for the biological consequences of poor vitamin K status. This deficiency might be caused by exhaustion of vitamin K due to its high requirements by vitamin K-dependent proteins to inhibit calcification. View Full-Text
Keywords: vitamin K; CKD; vascular calcification vitamin K; CKD; vascular calcification
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MDPI and ACS Style

Cozzolino, M.; Mangano, M.; Galassi, A.; Ciceri, P.; Messa, P.; Nigwekar, S. Vitamin K in Chronic Kidney Disease. Nutrients 2019, 11, 168.

AMA Style

Cozzolino M, Mangano M, Galassi A, Ciceri P, Messa P, Nigwekar S. Vitamin K in Chronic Kidney Disease. Nutrients. 2019; 11(1):168.

Chicago/Turabian Style

Cozzolino, Mario, Michela Mangano, Andrea Galassi, Paola Ciceri, Piergiorgio Messa, and Sagar Nigwekar. 2019. "Vitamin K in Chronic Kidney Disease" Nutrients 11, no. 1: 168.

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