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Nutrients 2019, 11(1), 168; https://doi.org/10.3390/nu11010168

Vitamin K in Chronic Kidney Disease

1
Renal Division, Department of Health Sciences, University of Milan, 20142 Milan, Italy
2
Renal Research Laboratory, Department of Nephrology, Dialysis and Renal Transplant, Fondazione IRCCS Ca’ Granda, Ospedale Maggiore Policlinico & Fondazione D’Amico per la Ricerca sulle Malattie Renali, 20122 Milan, Italy
3
Department of Medicine, Division of Nephrology, Massachusetts General Hospital, Boston, MA 02114, USA
*
Author to whom correspondence should be addressed.
Received: 16 November 2018 / Revised: 13 December 2018 / Accepted: 11 January 2019 / Published: 14 January 2019
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Abstract

Vitamin K is a composite term referring to a group of fat-soluble vitamins that function as a cofactor for the enzyme γ-glutamyl carboxylase (GGCX), which activates a number of vitamin K-dependent proteins (VKDPs) involved in haemostasis and vascular and bone health. Accumulating evidence demonstrates that chronic kidney disease (CKD) patients suffer from subclinical vitamin K deficiency, suggesting that this represents a population at risk for the biological consequences of poor vitamin K status. This deficiency might be caused by exhaustion of vitamin K due to its high requirements by vitamin K-dependent proteins to inhibit calcification. View Full-Text
Keywords: vitamin K; CKD; vascular calcification vitamin K; CKD; vascular calcification
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Cozzolino, M.; Mangano, M.; Galassi, A.; Ciceri, P.; Messa, P.; Nigwekar, S. Vitamin K in Chronic Kidney Disease. Nutrients 2019, 11, 168.

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