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Iodine Status during Pregnancy in a Region of Mild-to-Moderate Iodine Deficiency is not Associated with Adverse Obstetric Outcomes; Results from the Avon Longitudinal Study of Parents and Children (ALSPAC)

1
Institute of Applied Health Research, University of Birmingham, Birmingham B15 2TT, UK
2
Department of Nutritional Sciences, Faculty of Health and Medical Sciences, University of Surrey, Guildford, Surrey GU2 7XH, UK
3
Birmingham Heartlands Hospital, Birmingham B9 5SS, UK
4
Warwick Medical School, University of Warwick, Coventry CV4 7AL, UK
5
Institute of Metabolism and Systems Research, University of Birmingham, Birmingham B15 2TT, UK
6
Centre for Endocrinology, Diabetes and Metabolism, Birmingham Health Partners, Edgbaston, Birmingham B15 2TH, UK
7
Department of Obstetrics and Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, 1E Kent Ridge Road, Singapore 119228, Singapore
*
Author to whom correspondence should be addressed.
Nutrients 2018, 10(3), 291; https://doi.org/10.3390/nu10030291
Received: 31 January 2018 / Revised: 20 February 2018 / Accepted: 22 February 2018 / Published: 1 March 2018
(This article belongs to the Special Issue Iodine and Health throughout the Lifecourse)
Severe iodine deficiency during pregnancy has been associated with pregnancy/neonatal loss, and adverse pregnancy outcomes; however, the impact of mild–to–moderate iodine insufficiency, though prevalent in pregnancy, is not well-documented. We assessed whether mild iodine deficiency during pregnancy was associated with pregnancy/infant loss, or with other adverse pregnancy outcomes. We used samples and data from the Avon Longitudinal Study of Parents and Children (ALSPAC), from 3140 singleton pregnancies and from a further 42 women with pregnancy/infant loss. The group was classified as mildly-to-moderately iodine deficient with a median urinary iodine concentration of 95.3 µg/L (IQR 57.0–153.0; median urinary iodine-to-creatinine ratio (UI/Creat) 124 µg/g, IQR 82–198). The likelihood of pregnancy/infant loss was not different across four UI/Creat groups (<50, 50–149, 150–250, >250 µg/g). The incidence of pre-eclampsia, non-proteinuric gestational hypertension, gestational diabetes, glycosuria, anaemia, post-partum haemorrhage, preterm delivery, mode of delivery, being small for gestational age, and large for gestational age did not differ significantly among UI/Creat groups, nor were there any significant differences in the median UI/Creat. We conclude that maternal iodine status was not associated with adverse pregnancy outcomes in a mildly-to-moderately iodine-deficient pregnant population. However, in view of the low number of women with pregnancy/infant loss in our study, further research is required. View Full-Text
Keywords: iodine; pregnancy; obstetric; UK; Avon Longitudinal Study of Parents and Children (ALSPAC) iodine; pregnancy; obstetric; UK; Avon Longitudinal Study of Parents and Children (ALSPAC)
MDPI and ACS Style

Torlinska, B.; Bath, S.C.; Janjua, A.; Boelaert, K.; Chan, S.-Y. Iodine Status during Pregnancy in a Region of Mild-to-Moderate Iodine Deficiency is not Associated with Adverse Obstetric Outcomes; Results from the Avon Longitudinal Study of Parents and Children (ALSPAC). Nutrients 2018, 10, 291. https://doi.org/10.3390/nu10030291

AMA Style

Torlinska B, Bath SC, Janjua A, Boelaert K, Chan S-Y. Iodine Status during Pregnancy in a Region of Mild-to-Moderate Iodine Deficiency is not Associated with Adverse Obstetric Outcomes; Results from the Avon Longitudinal Study of Parents and Children (ALSPAC). Nutrients. 2018; 10(3):291. https://doi.org/10.3390/nu10030291

Chicago/Turabian Style

Torlinska, Barbara; Bath, Sarah C.; Janjua, Aisha; Boelaert, Kristien; Chan, Shiao-Yng. 2018. "Iodine Status during Pregnancy in a Region of Mild-to-Moderate Iodine Deficiency is not Associated with Adverse Obstetric Outcomes; Results from the Avon Longitudinal Study of Parents and Children (ALSPAC)" Nutrients 10, no. 3: 291. https://doi.org/10.3390/nu10030291

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