Next Article in Journal
Prospective Association between Total and Specific Dietary Polyphenol Intakes and Cardiovascular Disease Risk in the Nutrinet-Santé French Cohort
Previous Article in Journal
Diet Quality through Adolescence and Early Adulthood: Cross-Sectional Associations of the Dietary Approaches to Stop Hypertension Diet Index and Component Food Groups with Age
Open AccessArticle

Advanced Liver Fibrosis Is Independently Associated with Palmitic Acid and Insulin Levels in Patients with Non-Alcoholic Fatty Liver Disease

1
Institute of Nutrition Josué de Castro of Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro 21.941-902, Brazil
2
Nutrition Course, Federal University of Rio de Janeiro (Campus UFRJ-Macaé), Macaé, Rio de Janeiro 27.930-560, Brazil
3
Department of Internal Medicine, University Hospital Clementino Fraga Filho, School of Medicine of UFRJ, Rio de Janeiro 21.941-902, Brazil
4
Laboratory of Epigenetics of Lipid Metabolism, Madrid Institute for Advanced Studies (IMDEA)-Food, CEI UAM+CSIC, 28049 Madrid, Spain
*
Author to whom correspondence should be addressed.
Nutrients 2018, 10(11), 1586; https://doi.org/10.3390/nu10111586
Received: 24 September 2018 / Revised: 19 October 2018 / Accepted: 19 October 2018 / Published: 29 October 2018
Changes in lipid metabolism occur during the development and progression non-alcoholic fatty liver disease (NAFLD). However, the fatty acid (FA) profile in red blood cells (RBC) from patients with liver fibrosis remains unexplored. Thus, the goal of this study was to evaluate the fatty acid profile in RBC, dietary lipid intake and insulin resistance indicators in patients with NAFLD, according to the degree of hepatic fibrosis. Using elastography, patients were classified with (n = 52) and without (n = 37) advanced liver fibrosis. The fatty acid profile in RBC was analyzed using gas chromatography and the lipid intake was evaluated through a 24-h dietary recall. Subjects with advanced liver fibrosis had higher levels of palmitic, stearic and oleic acid and total monounsaturated fatty acid (MUFA) and insulin (p < 0.05), and lower levels of elongase very long chain fatty acids protein-6 and the delta-5-desaturase enzymatic activity (p < 0.05). These results suggest a lack of regulation of enzymes related to FA metabolism in patients with advanced fibrosis. View Full-Text
Keywords: non-alcoholic fatty liver disease; liver fibrosis; fatty acid composition; dietary lipids intake; nutritional assessment non-alcoholic fatty liver disease; liver fibrosis; fatty acid composition; dietary lipids intake; nutritional assessment
MDPI and ACS Style

Cansanção, K.; Silva Monteiro, L.; Carvalho Leite, N.; Dávalos, A.; Tavares do Carmo, M.D.G.; Arantes Ferreira Peres, W. Advanced Liver Fibrosis Is Independently Associated with Palmitic Acid and Insulin Levels in Patients with Non-Alcoholic Fatty Liver Disease. Nutrients 2018, 10, 1586.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop