The Mediterranean Ridge accretionary complex (MAC) is a product of the convergence of Africa–Europe–Aegean plates. As a result, the region exhibits a continuous mass change (horizontal/vertical movements) that generates earthquakes. Over the last 50 years, approximately 430 earthquakes with M ≥ 5, including 36 M ≥ 6 earthquakes, have been recorded in the region. This study aims to link the ocean bottom deformations manifested through ocean bottom pressure variations with the earthquakes’ time series. To this end, we investigated the time series of the ocean bottom pressure (OBP) anomalies derived from the Gravity Recovery and Climate Experiment (GRACE) and GRACE Follow-On (GRACE-FO) satellite missions. The OBP time series comprises a decreasing trend in addition to 1.02, 1.52, 4.27, and 10.66-year periodic components, which can be explained by atmosphere, oceans, and hydrosphere (AOH) processes, the Earth’s pole movement, solar activity, and core–mantle coupling. It can be inferred from the results that the OBP anomalies time series/mass change is linked to a rising trend and periods in the earthquakes’ energy time series. Based on this preliminary work, ocean-bottom pressure variation appears to be a promising lead for further research.
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