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Clinics and Practice, Volume 12, Issue 6

December 2022 - 25 articles

Cover Story: From the uterine tumor spectrum, one of the most aggressive entities is leiomyosarcoma. It represents one of the great public health problems worldwide, especially from the perspective of oncological treatment. These characteristics are accentuated by the possibility of the appearance of this neoplasm as a recurrence of a smooth muscle tumor with uncertain malignant potential. Our work presents the clinical, pathological and evolutionary characteristics of these two tumor types diagnosed over a period of 5 years. The study of the p53 pathogenic pathway and the tumor inflammatory infiltrate led to the indication of a new therapeutic target. Future studies are needed to identify therapies that will determine the favorable evolution of patients diagnosed with this pathology. View this paper
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Articles (25)

  • Article
  • Open Access
3 Citations
3,168 Views
15 Pages

25 November 2022

Situations often arise in intensive care units (ICUs) for which only sparse primary evidence or guidelines are applicable or to which existing evidence cannot be applied owing to interactions of multiple disease states. To improve and guide intensive...

  • Review
  • Open Access
27 Citations
26,038 Views
31 Pages

23 November 2022

Cancer is the third-leading cause of death in the United Arab Emirates (UAE); cancer care in the UAE has evolved dramatically over the last 40 years, from a single center in Al Ain in 1981 to more than 30 cancer centers and clinics across the UAE, wi...

  • Brief Report
  • Open Access
2 Citations
2,362 Views
5 Pages

Assessment of Nutritional Risk at ICU Admission and Mortality in Patients with Suspected COVID-19

  • Gustavo D. Pimentel,
  • Claude Pichard,
  • Paula M. Martins and
  • Emanoelly P. Franco

23 November 2022

Background/Objectives: The association between the nutritional risk and mortality in Brazilians with COVID-19 is poorly documented. Therefore, this study, for the first time, aimed at investigating the length of stay in the ICU and the chance of dyin...

  • Article
  • Open Access
2 Citations
3,325 Views
8 Pages

Assessment of Tissue Adequacy by EBUS in Conjunction with PET Scan and Operator’s Experience

  • Nagla Abdel Karim,
  • Asad Ullah,
  • Steven Pulliam,
  • Ahmed Mostafa,
  • Alejandro Aragaki,
  • Audrey Eubanks,
  • Amit Mahajan,
  • Mahmoud Shehata and
  • Sadia Benzaquen

20 November 2022

Mediastinal lymph node assessment is a crucial step in non-small cell lung cancer staging. Positron emission tomography (PET) has been the gold standard for the assessment of mediastinal lymphadenopathy, though it has limited specificity. Endobronchi...

  • Article
  • Open Access
12 Citations
4,997 Views
13 Pages

Dextrose Prolotherapy for Symptomatic Grade IV Knee Osteoarthritis: A Pilot Study of Early and Longer-Term Analgesia and Pain-Specific Cytokine Concentrations

  • Gastón Andrés Topol,
  • Ines Guerrero Pestalardo,
  • Kenneth Dean Reeves,
  • Fernando Elias,
  • Neven J. Steinmetz,
  • An-Lin Cheng and
  • David Rabago

14 November 2022

Background: Neurocytokines may upregulate or downregulate neuropathic pain. We hypothesized that dextrose (D-glucose) injections for therapeutic purposes (dextrose prolotherapy: DPT) in painful knee osteoarthritis (KOA) would favorably affect synovia...

  • Review
  • Open Access
2 Citations
3,341 Views
8 Pages

Current Understanding of “Mixed Corticomedullary Adrenal Tumor” and an Insight into Genomic Profiling

  • Asad Ullah,
  • Farah Ayman Elsaid Mohamed,
  • Jaffar Khan,
  • Katharine Tracy,
  • Muhabat Khan,
  • Samiha Mohsen,
  • Abdul Qahar Khan Yasinzai,
  • Kaleemullah Badini,
  • Philip T. Sobash and
  • Saleh Heneidi
  • + 1 author

11 November 2022

Background: Malignant mixed corticomedullary adrenal tumors (MCMTs) are extremely rare, with limited cases reported in the literature. The pathophysiology of malignant MCMTs is not well understood; the most prevailing theories are that it is a compos...

  • Article
  • Open Access
4 Citations
17,498 Views
10 Pages

The Effects of Isotretinoin on The Menstrual Cycle: A Cross-Sectional Study

  • Ghadah Alhetheli,
  • Sadin Alhazmi,
  • Shumukh Almutairi,
  • Samar Alharbi,
  • Norah Alharbi,
  • Maha Alsweed,
  • Mohammed Saleh Al-Dhubaibi,
  • Jolan Alsaud and
  • Lina Asiri

10 November 2022

Menstrual irregularities during isotretinoin therapy, including amenorrhea, can cause a great deal of health-status uncertainty such as the possibility of pregnancy. This study aimed to evaluate the effects of isotretinoin treatment on the menstrual...

  • Article
  • Open Access
4 Citations
3,854 Views
11 Pages

Five-Year Retrospective Study of Uterine STUMP and Leiomyosarcoma

  • Madalina Bosoteanu,
  • Mariana Deacu,
  • Raluca Ioana Voda,
  • Cristian Ionut Orasanu,
  • Mariana Aschie,
  • Sabina Elena Vlad,
  • Roxana Cleopatra Penciu and
  • Sergiu Ioachim Chirila

10 November 2022

Taking into account the unpredictable evolution of uterine STUMP and leiomyosarcomas, there are no clearly established therapeutic protocols to date, the only certified treatment being total hysterectomy. We performed a 5-year retrospective study inc...

  • Review
  • Open Access
4 Citations
4,944 Views
12 Pages

7 November 2022

Cancer research and clinical trials are essential to improve cancer patients’ outcomes and advance the oncology field. The United Arab Emirates (UAE) has been lagging in cancer research with many barriers, including healthcare, institutional, r...

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Clin. Pract. - ISSN 2039-7283