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Open AccessCase Report

Euglycemic Diabetic Ketoacidosis after a Single Dose of Empagliflozin in a Patient with Pancreatitis

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Internal Medicine Department, Centro Hospitalar de Entre o Douro e Vouga, 4520-211 Santa Maria da Feira, Portugal
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Surgery Department, Centro Hospitalar de Entre o Douro e Vouga, 4520-211 Santa Maria da Feira, Portugal
*
Author to whom correspondence should be addressed.
Academic Editor: Vishwanath Venketaraman
Clin. Pract. 2021, 11(2), 216-218; https://doi.org/10.3390/clinpract11020031
Received: 9 February 2021 / Revised: 22 March 2021 / Accepted: 29 March 2021 / Published: 6 April 2021
Sodium-glucose cotransporter 2 inhibitors (SGLT2i) are the most recently approved drug class for the treatment of type 2 diabetes mellitus (T2D). Although they are largely well-tolerated, their intake has been associated with euglycemic diabetic ketoacidosis (DKA) in some rare cases. We report the case of a 70-year-old male with type 2 diabetes and no history of DKA, who started therapy with empagliflozin one day before presenting with acute pancreatitis and laboratory findings consistent with euglycemic DKA. SGLT2i can induce euglycemic DKA from the first dose. Given the atypical presentation, a high degree of clinical suspicion is required to recognize this complication. View Full-Text
Keywords: diabetic ketoacidosis; sodium-glucose cotransporter 2 inhibitors; diabetes; empagliflozin diabetic ketoacidosis; sodium-glucose cotransporter 2 inhibitors; diabetes; empagliflozin
MDPI and ACS Style

Calçada, M.B.; Fernandes, L.; Soares Costa, R.; Montezinho, S.; Martins Duarte, F.; Frutuoso, L.; Freitas, A.R. Euglycemic Diabetic Ketoacidosis after a Single Dose of Empagliflozin in a Patient with Pancreatitis. Clin. Pract. 2021, 11, 216-218. https://doi.org/10.3390/clinpract11020031

AMA Style

Calçada MB, Fernandes L, Soares Costa R, Montezinho S, Martins Duarte F, Frutuoso L, Freitas AR. Euglycemic Diabetic Ketoacidosis after a Single Dose of Empagliflozin in a Patient with Pancreatitis. Clinics and Practice. 2021; 11(2):216-218. https://doi.org/10.3390/clinpract11020031

Chicago/Turabian Style

Calçada, Marta B.; Fernandes, Luís; Soares Costa, Rita; Montezinho, Sara; Martins Duarte, Filipa; Frutuoso, Luísa; Freitas, Ana R. 2021. "Euglycemic Diabetic Ketoacidosis after a Single Dose of Empagliflozin in a Patient with Pancreatitis" Clin. Pract. 11, no. 2: 216-218. https://doi.org/10.3390/clinpract11020031

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