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Open AccessReview

Malignant Phyllodes Tumor of the Breast: A Practice Review

1
Department of Medical Oncology, A.C.Camargo Cancer Center, São Paulo 01525-001, Brazil
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Department of Breast Surgery, A.C.Camargo Cancer Center, São Paulo 01525-001, Brazil
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Department of Anatomic Pathology A.C.Camargo Cancer Center, São Paulo 01525-001, Brazil
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Department of Radiation Oncology, A.C.Camargo Cancer Center, São Paulo 01525-001, Brazil
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Department of Oncogenetics, A.C.Camargo Cancer Center, São Paulo 01525-001, Brazil
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Department of Imaging, A.C.Camargo Cancer Center, São Paulo 01525-001, Brazil
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Institut Jules Bordet, Université Libre de Bruxelles (U.L.B.), 1050 Brussels, Belgium
*
Author to whom correspondence should be addressed.
Clin. Pract. 2021, 11(2), 205-215; https://doi.org/10.3390/clinpract11020030
Received: 19 February 2021 / Revised: 24 March 2021 / Accepted: 29 March 2021 / Published: 6 April 2021
Introduction: Phyllodes tumor (PT) of the breast, particularly malignant phyllodes tumor (mPT), is a rare fibroepithelial neoplasm. A complex diagnosis is based on pathologic, radiologic, and clinical findings, with controversies about what is the best therapeutic strategy. Objective: Our objective was to provide an overview of the clinical, pathologic, and therapeutic aspects of this rare tumor. Conclusions: mPT is a rare presentation of breast cancer and a challenge in clinical practice. A multidisciplinary approach should take into account some aspects like pathogenic mutations and hereditary syndromes. Oncologic surgery is the fundamental approach, and the use of adjuvant therapies is still controversial due to the lack of clinical trials. Treatment recommendations should be individualized according to patient risk and preferences. Prospective studies are fundamental to clarifying the best treatment for these tumors. View Full-Text
Keywords: Malignant phyllodes tumor; breast cancer; fibroepithelial neoplasm Malignant phyllodes tumor; breast cancer; fibroepithelial neoplasm
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MDPI and ACS Style

Fede, Â.B.d.S.; Pereira Souza, R.; Doi, M.; De Brot, M.; Aparecida Bueno de Toledo Osorio, C.; Rocha Melo Gondim, G.; Casali-da-Rocha, J.C.; Jbili, R.; Bitencourt, A.G.V.; Alves de Souza, J.; Caparica Bitton, R.; Baroni Alves Makdissi, F.; Moraes Sanches, S. Malignant Phyllodes Tumor of the Breast: A Practice Review. Clin. Pract. 2021, 11, 205-215. https://doi.org/10.3390/clinpract11020030

AMA Style

Fede ÂBdS, Pereira Souza R, Doi M, De Brot M, Aparecida Bueno de Toledo Osorio C, Rocha Melo Gondim G, Casali-da-Rocha JC, Jbili R, Bitencourt AGV, Alves de Souza J, Caparica Bitton R, Baroni Alves Makdissi F, Moraes Sanches S. Malignant Phyllodes Tumor of the Breast: A Practice Review. Clinics and Practice. 2021; 11(2):205-215. https://doi.org/10.3390/clinpract11020030

Chicago/Turabian Style

Fede, Ângelo B.d.S.; Pereira Souza, Ronaldo; Doi, Mauricio; De Brot, Marina; Aparecida Bueno de Toledo Osorio, Cynthia; Rocha Melo Gondim, Guilherme; Casali-da-Rocha, Jose C.; Jbili, Rima; Bitencourt, Almir G.V.; Alves de Souza, Juliana; Caparica Bitton, Rafael; Baroni Alves Makdissi, Fabiana; Moraes Sanches, Solange. 2021. "Malignant Phyllodes Tumor of the Breast: A Practice Review" Clin. Pract. 11, no. 2: 205-215. https://doi.org/10.3390/clinpract11020030

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