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In less than one year Antonio Cao (Cagliari, 4 May 1929–Cagliari, 21 June 2012) and Renzo Galanello (Parrano, 21 July 1948–Cagliari, 13 May 2013), two amongst the greatest scientists in the fields of Pediatrics, Hematology and Thalassemia, have passed away. Their deaths are an enormous loss for all of us in the Hospital for Microcitemias in Cagliari, but also for the whole Italian and International scientific community, who recognized and admired their leadership. During the funeral ceremonies held in our Hospital where both spent the greatest part of their lives, the most touching words were those pronounced by the patients who were cured by and benefited of the scrupulous medical care of our colleagues for decades from their infancy to adulthood [...]