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Audiology Research
Volume 2
Issue 1
10.4081/audiores.2012.e9
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Audiology Research is published by MDPI from Volume 10 Issue 2 (2020). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with PAGEPress.
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Article

Characteristics of Multiple Sclerosis Patient Stance Control Disorders, Measured by Means of Posturography and Related to Brainstem Lesions

by
Dario Alpini
1,
Federica Di Berardino
2,*,
Valentina Mattei
1,
Domenico Caputo
1,
Peter Schalek
3 and
Antonio Cesarani
2,4
1
Scientific Institute S. Maria Nascente, Don Carlo Gnocchi Foundation, Milan, Italy
2
Dipartimento di Scienze Chirurgiche Specialistiche, Università degli Studi di Milano, Milan, Italy
3
ENT Institute III Medical Faculty Charles University, Prague, Czech Republik
4
Audiology Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy
*
Author to whom correspondence should be addressed.
Audiol. Res. 2012, 2(1), e9; https://doi.org/10.4081/audiores.2012.e9
Submission received: 30 September 2011 / Revised: 30 December 2011 / Accepted: 3 January 2012 / Published: 13 January 2012

Abstract

Balance disorders are commonly observed during the course of multiple sclerosis (MS). The aim of this study is to report characteristics of MS patient stance control disorders, measured by means of posturography and related to the brainstem lesions. Thirty-eight patients affected by MS, mildly to moderately disable according to Kurtzke’s Expanded Disability Status Scale, underwent a complete clinical neurological and vestibular evaluation and brain MRI scanning. All patients were then tested on a static posturography platform (Tetrax, Israel) in four conditions: eyes open and eyes closed standing on a firm surface and on a foam pad. Clinical and/or magnetic resonance imaging evidence of brainstem involvement was observed in 55.3% of patients. When brainstem lesion was detected, Fourier analysis showed a typical pattern characterized by inversion of the 0-0.1 Hz and 0.1-0.25 Hz frequency bands. In conclusion, MS leads to pervasive postural disturbances in the majority of subjects, including the visuo-vestibular loops and proprioception involving vestibulospinal pathways in at least 55.3% of patients. Our results may also suggest the presence of Fourier inversion in patients with brainstem lesions.
Keywords: multiple sclerosis; magnetic resonance imaging; posturography; vestibulo-spinal reflex multiple sclerosis; magnetic resonance imaging; posturography; vestibulo-spinal reflex

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MDPI and ACS Style

Alpini, D.; Di Berardino, F.; Mattei, V.; Caputo, D.; Schalek, P.; Cesarani, A. Characteristics of Multiple Sclerosis Patient Stance Control Disorders, Measured by Means of Posturography and Related to Brainstem Lesions. Audiol. Res. 2012, 2, e9. https://doi.org/10.4081/audiores.2012.e9

AMA Style

Alpini D, Di Berardino F, Mattei V, Caputo D, Schalek P, Cesarani A. Characteristics of Multiple Sclerosis Patient Stance Control Disorders, Measured by Means of Posturography and Related to Brainstem Lesions. Audiology Research. 2012; 2(1):e9. https://doi.org/10.4081/audiores.2012.e9

Chicago/Turabian Style

Alpini, Dario, Federica Di Berardino, Valentina Mattei, Domenico Caputo, Peter Schalek, and Antonio Cesarani. 2012. "Characteristics of Multiple Sclerosis Patient Stance Control Disorders, Measured by Means of Posturography and Related to Brainstem Lesions" Audiology Research 2, no. 1: e9. https://doi.org/10.4081/audiores.2012.e9

APA Style

Alpini, D., Di Berardino, F., Mattei, V., Caputo, D., Schalek, P., & Cesarani, A. (2012). Characteristics of Multiple Sclerosis Patient Stance Control Disorders, Measured by Means of Posturography and Related to Brainstem Lesions. Audiology Research, 2(1), e9. https://doi.org/10.4081/audiores.2012.e9

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