A Case of Cutaneous Large B-Cell Lymphoma of the Legs Appearing as Chronic Venous Ulceration

Marta Carlesimo; Diego Orsini; Alessanrdra Narcisi; Claudia Abruzzese; Giorgia Cortesi; Gabriella De Marco; Alfredo Rossi

doi:10.4081/hr.2012.e6

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Case Report

24 April 2012

A Case of Cutaneous Large B-Cell Lymphoma of the Legs Appearing as Chronic Venous Ulceration

and

Dermatology Unit, S.Andrea Hospital, Faculty of Medicine and Psychology, University of Rome Sapienza, Via di Grottarossa, 1035, 00189 Rome, Italy

Author to whom correspondence should be addressed.

Hematol. Rep.2012, 4(2), e6;https://doi.org/10.4081/hr.2012.e6

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Abstract

We report here a case of a woman with a cutaneous large B-cell lymphoma of the legs. She had a plaque lesion, superficially ulcerated and necrotized with tumorous borders situated on the posterior side of the right leg and two red or bluish-red nodular lesions. A skin biopsy from both nodular and plaque lesion showed a diffuse infiltrate of atypical large B cells CD20⁺ and CD79a⁺, spanning epidermis, dermis and subcutaneous tissue. A therapeutic approach containing anti-CD20 monoclonal antibody (rituximab) was suggested.

Keywords:

primary cutaneous B cell lymphoma; B cell lymphoma of the leg; immunophenotype; therapy

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