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Hematology Reports
Volume 3
Issue 2
10.4081/hr.2011.e17
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Hematology Reports is published by MDPI from Volume 14 Issue 1 (2022). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with PAGEPress.
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Case Report

Chronic Eosinophilic Leukemia with FIP1L1-PDGFRA Transcripts after Occupational and Therapeutic Exposure to Radiation

by
Gueorgui Balatzenko
1,2,*,
Nikolay Stoyanov
2,3,
Elena Bekrieva
4 and
Margarita Guenova
2,3
1
Laboratory of Cytogenetics & Molecular Biology, National Specialized Hospital for Active Treatment of Hematological Diseases, 6, Plovdivsko Pole Str., 1756 Sofia, Bulgaria
2
Center of Excellence for Translational Research in Hematology, National Specialized Hospital for Active Treatment of Hematological Diseases, 6, Plovdivsko Pole Str., 1756 Sofia, Bulgaria
3
Laboratory of Haematopathology and Immunology, National Specialized Hospital for Active Treatment of Hematological Diseases, 6, Plovdivsko Pole Str., 1756 Sofia, Bulgaria
4
Clinic of Hematology, National Specialized Hospital for Active Treatment of Hematological Diseases, 6, Plovdivsko Pole Str., 1756 Sofia, Bulgaria
*
Author to whom correspondence should be addressed.
Hematol. Rep. 2011, 3(2), e17; https://doi.org/10.4081/hr.2011.e17
Submission received: 14 June 2011 / Revised: 10 September 2011 / Accepted: 15 September 2011 / Published: 11 October 2011

Abstract

We present for the first time a 40-year-old male patient with a 20 year history of occupational exposure to radiation as a nuclear power plant worker, who developed FIP1L1-PDGFRA-positive chronic eosinophilic leukaemia 27 months after radiotherapy for testicular seminoma. After an one-year history of dry cough, itching and night sweats, the patient presented with an elevated leukocyte count with absolute eosinophilia of 14.2 × 109/L, bone marrow and lymph node involvement. Treatment with Imatinib was initiated, resulting in complete haematological remission at the sixth month and complete molecular response by nested primers reverse transcription polymerase chain reaction–at the end of the first year. This case contributes for the clinical heterogeneity of FIP1L1-PDGFA–positive myeloproliferative neoplasms and the possible role of occupational and therapeutic radiation, raising the question if one or both of them might be the causative factor.
Keywords: chronic eosinophilic leukemia; FIP1L1-PDGFRA; therapy-related myeloproliferative neoplasm; radiation exposure chronic eosinophilic leukemia; FIP1L1-PDGFRA; therapy-related myeloproliferative neoplasm; radiation exposure

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MDPI and ACS Style

Balatzenko, G.; Stoyanov, N.; Bekrieva, E.; Guenova, M. Chronic Eosinophilic Leukemia with FIP1L1-PDGFRA Transcripts after Occupational and Therapeutic Exposure to Radiation. Hematol. Rep. 2011, 3, e17. https://doi.org/10.4081/hr.2011.e17

AMA Style

Balatzenko G, Stoyanov N, Bekrieva E, Guenova M. Chronic Eosinophilic Leukemia with FIP1L1-PDGFRA Transcripts after Occupational and Therapeutic Exposure to Radiation. Hematology Reports. 2011; 3(2):e17. https://doi.org/10.4081/hr.2011.e17

Chicago/Turabian Style

Balatzenko, Gueorgui, Nikolay Stoyanov, Elena Bekrieva, and Margarita Guenova. 2011. "Chronic Eosinophilic Leukemia with FIP1L1-PDGFRA Transcripts after Occupational and Therapeutic Exposure to Radiation" Hematology Reports 3, no. 2: e17. https://doi.org/10.4081/hr.2011.e17

APA Style

Balatzenko, G., Stoyanov, N., Bekrieva, E., & Guenova, M. (2011). Chronic Eosinophilic Leukemia with FIP1L1-PDGFRA Transcripts after Occupational and Therapeutic Exposure to Radiation. Hematology Reports, 3(2), e17. https://doi.org/10.4081/hr.2011.e17

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