Next Article in Journal
The Reproduction in Women Affected by Cooley Disease
Previous Article in Journal
Osteopetrosis: A Rare Cause of Anemia
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Hematology Reports
Volume 3
Issue 1
10.4081/hr.2011.e2
hematolrep-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles thumb_up
...
Endorse textsms
...
Comment
Hematology Reports is published by MDPI from Volume 14 Issue 1 (2022). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with PAGEPress.
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Case Report

Severe Isoniazid Related Sideroblastic Anemia

by
Rein Jan Piso
1,*,
Kveti Kriz
2 and
Marie-Claire Desax
2
1
Department of Medicine, Infectiology, Kantonsspital, 4600 Olten, Switzerland
2
Department of Medicine, Haematology, Kantonsspital, 4600 Olten, Switzerland
*
Author to whom correspondence should be addressed.
Hematol. Rep. 2011, 3(1), e2; https://doi.org/10.4081/hr.2011.e2
Submission received: 30 September 2010 / Revised: 20 December 2010 / Accepted: 14 January 2011 / Published: 21 January 2011

Abstract

Isoniazid induced sideroblastic anemia is a rare event. We report case of a 45 year old Caucasian women with development of severe anaemia 4 month after introduction of Isoniazid as part of Tuberculosis treatment. While haemoglobin fell to 47 g/L and erythrocyte count to 1.5 G/L, reticulocytes were very low (reticulocyte production index of 0.48), but bone marrow aspirate showed an accelerated erythropoiesis with ringsideroblasts. Anaemia rapidly resolved after cessation of Isoniazid. We postulate an Isoniazid induced inhibition of the δ-Amino-levulinat-synthase resulting in marked depletion of heam synthesis.
Keywords: sideroblastic anaemia; isoniazid; tuberculosis sideroblastic anaemia; isoniazid; tuberculosis

Share and Cite

MDPI and ACS Style

Piso, R.J.; Kriz, K.; Desax, M.-C. Severe Isoniazid Related Sideroblastic Anemia. Hematol. Rep. 2011, 3, e2. https://doi.org/10.4081/hr.2011.e2

AMA Style

Piso RJ, Kriz K, Desax M-C. Severe Isoniazid Related Sideroblastic Anemia. Hematology Reports. 2011; 3(1):e2. https://doi.org/10.4081/hr.2011.e2

Chicago/Turabian Style

Piso, Rein Jan, Kveti Kriz, and Marie-Claire Desax. 2011. "Severe Isoniazid Related Sideroblastic Anemia" Hematology Reports 3, no. 1: e2. https://doi.org/10.4081/hr.2011.e2

APA Style

Piso, R. J., Kriz, K., & Desax, M. -C. (2011). Severe Isoniazid Related Sideroblastic Anemia. Hematology Reports, 3(1), e2. https://doi.org/10.4081/hr.2011.e2

Article Metrics

Back to TopTop