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Hematology Reports
Volume 3
Issue 1
10.4081/hr.2011.e4
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Hematology Reports is published by MDPI from Volume 14 Issue 1 (2022). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with PAGEPress.
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Brief Report

The Reproduction in Women Affected by Cooley Disease

by
Carlo Pafumi
1,2,*,
Vito Leanza
1,
Luana Coco
1,
Stefania Vizzini
1,
Lilliana Ciotta
1,
Alessandra Messina
1,
Gianluca Leanza
1,
Giuseppe Zarbo
1,
Alfio D'Agati
1,
Marco Antonio Palumbo
3,
Alessandra Iemmola
3,
Ferdinando Antonio Gulino
3,
Maria Cristina Teodoro
3,
Matthew Attard
4,
Alina Cristina Plesca
5,
Catarina Soares
6,
Nina Kouloubis
7 and
Mayada Chammas
8
1
Department of Obstetrics and Gynaecology, University of Catania, 95124 Catania, Italy
2
Surgery Department, Vittorio Emanuel Hopsital, Via Plebiscito, 95122 Catania, Italy
3
Department of Assisted Reproduction, University of Catania, 95124 Catania, Italy
4
Faculty of Medicine & Surgery, University of Malta, 2080 Msida, Malta
5
Faculty of Medicine, University of Medicine and Pharmacy GR.T.Popa Iasi, 700115 Iași, Romania
6
Faculdade de Medicina da Universidade do Porto, 4099-002 Porto, Portugal
7
University of Rotterdam, 3062 PA Rotterdam, The Netherlands
8
University of Beirut, Israel
*
Author to whom correspondence should be addressed.
Hematol. Rep. 2011, 3(1), e4; https://doi.org/10.4081/hr.2011.e4
Submission received: 1 January 2011 / Revised: 7 March 2011 / Accepted: 9 May 2011 / Published: 23 March 2011

Abstract

The health background management and outcomes of 5 pregnancies in 4 women affected by Cooley Disease, from Paediatric Institute of Catania University, are described, considering the preconceptual guidances and cares for such patients. These patients were selected among a group of 100 thalassemic women divided into three subgroups, according to their first and successive menstruation characteristics: (i) patients with primitive amenorrhoea, (ii) patients with secondary amenorrhoea and (iii) patients with normal menstruation. Only one woman, affected by primitive amenorrhoea, needed the induction of ovulation. A precise and detailed pre-pregnancy assessment was effected before each conception. This was constituted by a series of essays, including checks for diabetes and hypothyroidism, for B and C hepatitis and for blood group antibodies. Moreover were evaluated: cardiac function, rubella immunity and transaminases. Other pregnancy monitoring, and cares during labour and delivery were effected according to usual obstetrics practice. All the women were in labour when she were 38 week pregnant, and the outcome were five healthy babies born at term, weighting between 2600 and 3200 gs. The only complication was the Caesarean section. The improvements of current treatments, especially in the management of iron deposits, the prolongation of survival rate, will result in a continuous increase of pregnancies in thalassemic women. Pregnancy is now a real possibility for women affected by such disease. We are furthermore studying the possibility to collect the fetus' umbilical cord blood, after the delivery, to attempt eterologus transplantation to his mother trying to get a complete marrow reconstitution.
Keywords: beta-thalassemia major; fertility; pregnancy; umbilical cord blood; transplantation; marrow reconstitution beta-thalassemia major; fertility; pregnancy; umbilical cord blood; transplantation; marrow reconstitution

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MDPI and ACS Style

Pafumi, C.; Leanza, V.; Coco, L.; Vizzini, S.; Ciotta, L.; Messina, A.; Leanza, G.; Zarbo, G.; D'Agati, A.; Palumbo, M.A.; et al. The Reproduction in Women Affected by Cooley Disease. Hematol. Rep. 2011, 3, e4. https://doi.org/10.4081/hr.2011.e4

AMA Style

Pafumi C, Leanza V, Coco L, Vizzini S, Ciotta L, Messina A, Leanza G, Zarbo G, D'Agati A, Palumbo MA, et al. The Reproduction in Women Affected by Cooley Disease. Hematology Reports. 2011; 3(1):e4. https://doi.org/10.4081/hr.2011.e4

Chicago/Turabian Style

Pafumi, Carlo, Vito Leanza, Luana Coco, Stefania Vizzini, Lilliana Ciotta, Alessandra Messina, Gianluca Leanza, Giuseppe Zarbo, Alfio D'Agati, Marco Antonio Palumbo, and et al. 2011. "The Reproduction in Women Affected by Cooley Disease" Hematology Reports 3, no. 1: e4. https://doi.org/10.4081/hr.2011.e4

APA Style

Pafumi, C., Leanza, V., Coco, L., Vizzini, S., Ciotta, L., Messina, A., Leanza, G., Zarbo, G., D'Agati, A., Palumbo, M. A., Iemmola, A., Gulino, F. A., Teodoro, M. C., Attard, M., Plesca, A. C., Soares, C., Kouloubis, N., & Chammas, M. (2011). The Reproduction in Women Affected by Cooley Disease. Hematology Reports, 3(1), e4. https://doi.org/10.4081/hr.2011.e4

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