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International Journal of Plant Biology is published by MDPI from Volume 13 Issue 1 (2022). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with PAGEPress.
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Article

Antioxidant, Enzyme-Inhibitory and Antitumor Activity of the Wild Dietary Plant Muscari comosum (L.) Mill.

by
Teresa Casacchia
1,
Adriano Sofo
2,
Ivan Casaburi
1,
Mariangela Marrelli
1,
Filomena Conforti
1 and
Giancarlo A. Statti
1,*
1
Department of Pharmacy, Health and Nutrition Sciences, University of Calabria, via Pietro Bucci, 87036 Rende, CS, Italy
2
School of Agricultural, Forestry, Food and Environmental Sciences, University of Basilicata, 85100 Potenza, PZ, Italy
*
Author to whom correspondence should be addressed.
Int. J. Plant Biol. 2017, 8(1), 6895; https://doi.org/10.4081/pb.2017.6895
Submission received: 20 September 2016 / Revised: 24 October 2016 / Accepted: 24 October 2016 / Published: 12 April 2017

Abstract

Conventional medicines used to treat obesity and cancer frequently exhibit high side effects, so that researchers are focusing on new therapies and drugs based on natural products. Total extracts from bulbs of Muscari comosum were tested for (i) free radical scavenging activity, (ii) in vitro enzymatic inhibition of pancreatic α-amylase and lipase, and (iii) inhibition of the growth of breast adenocarcinoma cells. Three treatments were considered: bulbs boiled in water for 15 min (traditional cooking method; BB); bulbs steam-cooked for 15 min (alternative cooking method; SB); raw bulbs (RB). The polyphenol content and antioxidant capacity of bulb extracts were related to the inhibition of pancreatic lipase and α-amylase, whose activities have been found to have a half maximal inhibitory concentration (IC50) of 0.28, 2.14 and 3.22 mg/mL for lipase, and 0.16, 0.73 and 0.69 mg/mL for α-amylase in RB, SB and BB, respectively. The analysis on breast adenocarcinoma MCF-7 cells revealed that RB extracts, and in a lesser extent BB, exerted a dose-dependent inhibition on cell proliferation. Considering that the potential of natural products for the treatment of obesity are under exploration, M. comosum could be an excellent plant for the development of future anti-obesity drugs, also able to prevent cancer.
Keywords: α-amylase; antioxidant; cancer; Muscari comosum; pancreatic lipase; phenols α-amylase; antioxidant; cancer; Muscari comosum; pancreatic lipase; phenols

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MDPI and ACS Style

Casacchia, T.; Sofo, A.; Casaburi, I.; Marrelli, M.; Conforti, F.; Statti, G.A. Antioxidant, Enzyme-Inhibitory and Antitumor Activity of the Wild Dietary Plant Muscari comosum (L.) Mill. Int. J. Plant Biol. 2017, 8, 6895. https://doi.org/10.4081/pb.2017.6895

AMA Style

Casacchia T, Sofo A, Casaburi I, Marrelli M, Conforti F, Statti GA. Antioxidant, Enzyme-Inhibitory and Antitumor Activity of the Wild Dietary Plant Muscari comosum (L.) Mill. International Journal of Plant Biology. 2017; 8(1):6895. https://doi.org/10.4081/pb.2017.6895

Chicago/Turabian Style

Casacchia, Teresa, Adriano Sofo, Ivan Casaburi, Mariangela Marrelli, Filomena Conforti, and Giancarlo A. Statti. 2017. "Antioxidant, Enzyme-Inhibitory and Antitumor Activity of the Wild Dietary Plant Muscari comosum (L.) Mill." International Journal of Plant Biology 8, no. 1: 6895. https://doi.org/10.4081/pb.2017.6895

APA Style

Casacchia, T., Sofo, A., Casaburi, I., Marrelli, M., Conforti, F., & Statti, G. A. (2017). Antioxidant, Enzyme-Inhibitory and Antitumor Activity of the Wild Dietary Plant Muscari comosum (L.) Mill. International Journal of Plant Biology, 8(1), 6895. https://doi.org/10.4081/pb.2017.6895

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