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Article

Tissue Adhesive, Self-Healing, Biocompatible, Hemostasis, and Antibacterial Properties of Fungal-Derived Carboxymethyl Chitosan-Polydopamine Hydrogels

1
School of Chemical Engineering, Yeungnam University, Gyeongsan 38541, Korea
2
Research Institute of Cell Culture, Yeungnam University, Gyeongsan 38541, Korea
3
College of Pharmacy, Yeungnam University, Gyeongsan 38541, Korea
4
Department of Medical Biotechnology, Yeungnam University, Gyeongsan 38541, Korea
*
Author to whom correspondence should be addressed.
Academic Editors: Patrizia Paolicelli and Maria Antonietta Casadei
Pharmaceutics 2022, 14(5), 1028; https://doi.org/10.3390/pharmaceutics14051028
Received: 31 March 2022 / Revised: 5 May 2022 / Accepted: 6 May 2022 / Published: 10 May 2022
In this work, fungal mushroom-derived carboxymethyl chitosan-polydopamine hydrogels (FCMCS-PDA) with multifunctionality (tissue adhesive, hemostasis, self-healing, and antibacterial properties) were developed for wound dressing applications. The hydrogel is obtained through dynamic Schiff base cross-linking and hydrogen bonds between FCMCS-PDA and covalently cross-linked polyacrylamide (PAM) networks. The FCMCS-PDA-PAM hydrogels have a good swelling ratio, biodegradable properties, excellent mechanical properties, and a highly interconnected porous structure with PDA microfibrils. Interestingly, the PDA microfibrils were formed along with FCMCS fibers in the hydrogel networks, which has a high impact on the biological performance of hydrogels. The maximum adhesion strength of the hydrogel to porcine skin was achieved at about 29.6 ± 2.9 kPa. The hydrogel had good self-healing and recoverable properties. The PDA-containing hydrogels show good antibacterial properties on Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) bacteria. Moreover, the adhesive hydrogels depicted good viability and attachment of skin fibroblasts and keratinocyte cells. Importantly, FCMCS and PDA combined resulted in fast blood coagulation within 60 s. Hence, the adhesive hydrogel with multifunctionality has excellent potential as a wound dressing material for infected wounds. View Full-Text
Keywords: mussel inspired; polydopamine; non-animal fungal mushroom carboxymethyl chitosan; hydrogel; tissue adhesive; wound dressing applications mussel inspired; polydopamine; non-animal fungal mushroom carboxymethyl chitosan; hydrogel; tissue adhesive; wound dressing applications
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MDPI and ACS Style

Rao, K.M.; Narayanan, K.B.; Uthappa, U.T.; Park, P.-H.; Choi, I.; Han, S.S. Tissue Adhesive, Self-Healing, Biocompatible, Hemostasis, and Antibacterial Properties of Fungal-Derived Carboxymethyl Chitosan-Polydopamine Hydrogels. Pharmaceutics 2022, 14, 1028. https://doi.org/10.3390/pharmaceutics14051028

AMA Style

Rao KM, Narayanan KB, Uthappa UT, Park P-H, Choi I, Han SS. Tissue Adhesive, Self-Healing, Biocompatible, Hemostasis, and Antibacterial Properties of Fungal-Derived Carboxymethyl Chitosan-Polydopamine Hydrogels. Pharmaceutics. 2022; 14(5):1028. https://doi.org/10.3390/pharmaceutics14051028

Chicago/Turabian Style

Rao, Kummara M., Kannan B. Narayanan, Uluvangada T. Uthappa, Pil-Hoon Park, Inho Choi, and Sung S. Han. 2022. "Tissue Adhesive, Self-Healing, Biocompatible, Hemostasis, and Antibacterial Properties of Fungal-Derived Carboxymethyl Chitosan-Polydopamine Hydrogels" Pharmaceutics 14, no. 5: 1028. https://doi.org/10.3390/pharmaceutics14051028

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