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Article

Dexamethasone-Loaded Ureasil Hydrophobic Membrane for Bone Guided Regeneration

1
Pharmaceutical Sciences Postgraduate Center for Biological and Health Sciences, State University of Paraíba, Av. Juvêncio Arruda, S/N, Campina Grande 58429-600, Paraíba, Brazil
2
Department of Drugs and Medicines, School of Pharmaceutical Sciences, São Paulo State University (UNESP), Highway Araraquara-Jaú, Araraquara 14801-902, São Paulo, Brazil
3
Department of Pharmacy, Federal University of Rio Grande do Norte-UFRN, Natal 59012-570, Rio Grande do Norte, Brazil
4
Faculty of Dentistry, São Paulo State University (UNESP), Araraquara 14801-385, São Paulo, Brazil
*
Authors to whom correspondence should be addressed.
Academic Editors: Isabel Izquierdo-Barba and Marina Gallarate
Pharmaceutics 2022, 14(5), 1027; https://doi.org/10.3390/pharmaceutics14051027
Received: 28 March 2022 / Revised: 7 May 2022 / Accepted: 9 May 2022 / Published: 10 May 2022
(This article belongs to the Special Issue Drug Discovery and Drug Delivery System for Biological Application)
Physical barrier membranes have been used to release active substances to treat critical bone defects; however, hydrophilic membranes do not present a prolonged release capacity. In this sense, hydrophobic membranes have been tested. Thus, this study aimed to develop hydrophobic membranes based on mixtures of ureasil–polyether-type materials containing incorporated dexamethasone (DMA) for the application in guided bone regeneration. The physicochemical characterization and biological assays were carried out using small-angle X-ray scattering (SAXS), an in vitro DMA release study, atomic force microscopy (AFM), a hemolysis test, and in vivo bone formation. The swelling degree, SAXS, and release results revealed that the u-PPO400/2000 membrane in the proportion of 70:30 showed swelling (4.69% ± 0.22) similar to the proportions 90:10 and 80:20, and lower than the proportion 60:40 (6.38% ± 0.49); however, an equal release percentage after 134 h was observed between the proportions 70:30 and 60:40. All u-PPO materials presented hemocompatibility (hemolysis ≤2.8%). AFM results showed that the treatments with or without DMA did not present significant differences, revealing a flat/smooth surface, with no pores and/or crystalline precipitates. Finally, in vivo results revealed that for both the commercial hydrophilic membrane and u-PPO400/2000 (70:30) after 60 days, the bone formation volume was 21%. In conclusion, hybrid membranes present unique characteristics for treating critical bone defects, considering the delayed and prolonged release results associated with the physical barrier capacity. View Full-Text
Keywords: critical bone defect size; hydrophobic membrane; organic–inorganic hybrid materials critical bone defect size; hydrophobic membrane; organic–inorganic hybrid materials
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MDPI and ACS Style

Barros, R.M.; Da Silva, C.G.; Nicolau Costa, K.M.; Da Silva-Junior, A.A.; Scardueli, C.R.; Marcantonio, R.A.C.; Chiavacci, L.A.; Oshiro-Junior, J.A. Dexamethasone-Loaded Ureasil Hydrophobic Membrane for Bone Guided Regeneration. Pharmaceutics 2022, 14, 1027. https://doi.org/10.3390/pharmaceutics14051027

AMA Style

Barros RM, Da Silva CG, Nicolau Costa KM, Da Silva-Junior AA, Scardueli CR, Marcantonio RAC, Chiavacci LA, Oshiro-Junior JA. Dexamethasone-Loaded Ureasil Hydrophobic Membrane for Bone Guided Regeneration. Pharmaceutics. 2022; 14(5):1027. https://doi.org/10.3390/pharmaceutics14051027

Chicago/Turabian Style

Barros, Rafaella M., Camila G. Da Silva, Kammila M. Nicolau Costa, Arnóbio A. Da Silva-Junior, Cássio R. Scardueli, Rosemary A.C. Marcantonio, Leila A. Chiavacci, and João A. Oshiro-Junior. 2022. "Dexamethasone-Loaded Ureasil Hydrophobic Membrane for Bone Guided Regeneration" Pharmaceutics 14, no. 5: 1027. https://doi.org/10.3390/pharmaceutics14051027

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