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Article

In-Depth Comparison of Dry Particle Coating Processes Used in DPI Particle Engineering

1
Department of Pharmaceutics and Biopharmaceutics, Kiel University, Grasweg 9a, 24118 Kiel, Germany
2
Meggle Excipients and Technology, 83512 Wasserburg, Germany
*
Author to whom correspondence should be addressed.
Academic Editor: Stefano Giovagnoli
Pharmaceutics 2021, 13(4), 580; https://doi.org/10.3390/pharmaceutics13040580
Received: 18 March 2021 / Revised: 8 April 2021 / Accepted: 16 April 2021 / Published: 19 April 2021
(This article belongs to the Special Issue Advanced Characterization of Inhalation Medicinal Products)
High-shear mixer coatings as well as mechanofusion processes are used in the particle-engineering of dry powder inhalation carrier systems. The aim of coating the carrier particle is usually to decrease carrier–drug adhesion. This study comprises the in-depth comparison of two established dry particle coating options. Both processes were conducted with and without a model additive (magnesium stearate). In doing so, changes in the behaviour of the processed particles can be traced back to either the process or the additive. It can be stated that the coarse model carrier showed no significant changes when processed without additives. By coating the particles with magnesium stearate, the surface energy decreased significantly. This leads to a significant enhancement of the aerodynamic performance of the respective carrier-based blends. Comparing the engineered carriers with each other, the high-shear mixer coating shows significant benefits, namely, lower drug–carrier adhesion and the higher efficiency of the coating process. View Full-Text
Keywords: dry powder inhalation; compound excipient; force control agent; surface energy; adhesion strength dry powder inhalation; compound excipient; force control agent; surface energy; adhesion strength
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MDPI and ACS Style

Bungert, N.; Kobler, M.; Scherließ, R. In-Depth Comparison of Dry Particle Coating Processes Used in DPI Particle Engineering. Pharmaceutics 2021, 13, 580. https://doi.org/10.3390/pharmaceutics13040580

AMA Style

Bungert N, Kobler M, Scherließ R. In-Depth Comparison of Dry Particle Coating Processes Used in DPI Particle Engineering. Pharmaceutics. 2021; 13(4):580. https://doi.org/10.3390/pharmaceutics13040580

Chicago/Turabian Style

Bungert, Nicholas, Mirjam Kobler, and Regina Scherließ. 2021. "In-Depth Comparison of Dry Particle Coating Processes Used in DPI Particle Engineering" Pharmaceutics 13, no. 4: 580. https://doi.org/10.3390/pharmaceutics13040580

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