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Open AccessArticle

Effect of Curcumin Nanoemulsions Stabilized with MAG and DAG-MCFAs in a Fructose-Induced Hepatic Steatosis Rat Model

1
UNIDA, Tecnológico Nacional de México, Instituto Tecnológico de Veracruz, Miguel Ángel de Quevedo 2779, Veracruz, Ver. 91897, Mexico
2
Instituto de Investigaciones Medico Biológicas, Universidad Veracruzana, Iturbide s/n, Veracruz, Ver. 91700, Mexico
3
Tecnológico de Monterrey, Escuela de Ingeniería y Ciencias, Av. General Ramón Corona 2514, Nuevo México, Zapopan, Jalisco 45138, Mexico
4
Tecnológico de Monterrey, Escuela de Ingeniería y Ciencias, Ave. Eugenio Garza Sada 2501, Monterrey, N.L. 64849, Mexico
5
Facultad de Bioanálisis, Iturbide S/N, Col. Centro, Universidad Veracruzana, Veracruz, Ver. 91700, Mexico
*
Authors to whom correspondence should be addressed.
Academic Editors: Fiona McCartney and John Gleeson
Pharmaceutics 2021, 13(4), 509; https://doi.org/10.3390/pharmaceutics13040509
Received: 4 March 2021 / Revised: 1 April 2021 / Accepted: 6 April 2021 / Published: 8 April 2021
(This article belongs to the Special Issue Pre-clinical Pharmacology and Pharmacokinetics in Oral Drug Delivery)
Current changes in diet, characterized by an increase in the intake of sweetened beverages, are heavily related to metabolic disorders such as non-alcoholic fatty liver. This condition can produce simple steatosis and, in worse cases, potentially result in steatohepatitis, fibrosis, and cirrhosis, comparable to the damage caused by the consumption of more or less 20–30 g of alcohol per day. The main objective of this research was to evaluate the effect of curcumin (Curcuma longa) nanoemulsions, using mono- and diacylglycerides medium chain fatty acids as stabilizers in an in vivo hepatic steatosis rat model. Pathology was induced by providing 30% fructose intake in the drinking water. Globule sizes under 200 nm that were stable for 4 weeks were obtained; curcumin encapsulated in the nanoemulsion was >70%. The results revealed an improvement regarding body and liver weight in the animals treated with curcumin nanoemulsions. A decrease in total cholesterol, LDL, AST/ALT, and HDL in serum was observed; however, no apparent improvement regarding serum glucose or triacylglycerides values was noted. Histological analysis showed a significant decrease in the extent of steatosis, inflammation, and brown adipose tissue in the treated animals. View Full-Text
Keywords: curcumin; hepatic steatosis; mono- and diacylglycerides; medium chain triglycerides; fructose; nanoemulsion curcumin; hepatic steatosis; mono- and diacylglycerides; medium chain triglycerides; fructose; nanoemulsion
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MDPI and ACS Style

Agame-Lagunes, B.; Grube-Pagola, P.; García-Varela, R.; Alexander-Aguilera, A.; García, H.S. Effect of Curcumin Nanoemulsions Stabilized with MAG and DAG-MCFAs in a Fructose-Induced Hepatic Steatosis Rat Model. Pharmaceutics 2021, 13, 509. https://doi.org/10.3390/pharmaceutics13040509

AMA Style

Agame-Lagunes B, Grube-Pagola P, García-Varela R, Alexander-Aguilera A, García HS. Effect of Curcumin Nanoemulsions Stabilized with MAG and DAG-MCFAs in a Fructose-Induced Hepatic Steatosis Rat Model. Pharmaceutics. 2021; 13(4):509. https://doi.org/10.3390/pharmaceutics13040509

Chicago/Turabian Style

Agame-Lagunes, Beatriz; Grube-Pagola, Peter; García-Varela, Rebeca; Alexander-Aguilera, Alfonso; García, Hugo S. 2021. "Effect of Curcumin Nanoemulsions Stabilized with MAG and DAG-MCFAs in a Fructose-Induced Hepatic Steatosis Rat Model" Pharmaceutics 13, no. 4: 509. https://doi.org/10.3390/pharmaceutics13040509

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