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Review

Delivery Systems for Nucleic Acids and Proteins: Barriers, Cell Capture Pathways and Nanocarriers

1
Grupo de Diseño de Productos y Procesos (GDPP), Department of Chemical and Food Engineering, Universidad de los Andes, Bogotá 111711, Colombia
2
Department of Biomedical Engineering, Universidad de los Andes, Bogotá 111711, Colombia
*
Authors to whom correspondence should be addressed.
Academic Editor: Winfried Neuhaus
Pharmaceutics 2021, 13(3), 428; https://doi.org/10.3390/pharmaceutics13030428
Received: 9 February 2021 / Revised: 9 March 2021 / Accepted: 12 March 2021 / Published: 22 March 2021
(This article belongs to the Special Issue Biological Barriers in Health and Disease)
Gene therapy has been used as a potential approach to address the diagnosis and treatment of genetic diseases and inherited disorders. In this line, non-viral systems have been exploited as promising alternatives for delivering therapeutic transgenes and proteins. In this review, we explored how biological barriers are effectively overcome by non-viral systems, usually nanoparticles, to reach an efficient delivery of cargoes. Furthermore, this review contributes to the understanding of several mechanisms of cellular internalization taken by nanoparticles. Because a critical factor for nanoparticles to do this relies on the ability to escape endosomes, researchers have dedicated much effort to address this issue using different nanocarriers. Here, we present an overview of the diversity of nanovehicles explored to reach an efficient and effective delivery of both nucleic acids and proteins. Finally, we introduced recent advances in the development of successful strategies to deliver cargoes. View Full-Text
Keywords: gene therapy; internalization; nanovehicles; delivery gene therapy; internalization; nanovehicles; delivery
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MDPI and ACS Style

Torres-Vanegas, J.D.; Cruz, J.C.; Reyes, L.H. Delivery Systems for Nucleic Acids and Proteins: Barriers, Cell Capture Pathways and Nanocarriers. Pharmaceutics 2021, 13, 428. https://doi.org/10.3390/pharmaceutics13030428

AMA Style

Torres-Vanegas JD, Cruz JC, Reyes LH. Delivery Systems for Nucleic Acids and Proteins: Barriers, Cell Capture Pathways and Nanocarriers. Pharmaceutics. 2021; 13(3):428. https://doi.org/10.3390/pharmaceutics13030428

Chicago/Turabian Style

Torres-Vanegas, Julian D.; Cruz, Juan C.; Reyes, Luis H. 2021. "Delivery Systems for Nucleic Acids and Proteins: Barriers, Cell Capture Pathways and Nanocarriers" Pharmaceutics 13, no. 3: 428. https://doi.org/10.3390/pharmaceutics13030428

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