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Article

Zein Nanoparticles Improve the Oral Bioavailability of Curcumin in Wistar Rats

1
Nucaps Nanotechnology S.L., 31110 Noain, Spain
2
Center for Nutrition Research, University of Navarra, 31008 Pamplona, Spain
3
Drug Development Unit, Department of Pharmacology and Toxicology, Faculty of Pharmacy and Nutrition, University of Navarra, 31008 Pamplona, Spain
4
Inserm U1070, Pôle Biologie Santé, Université de Poitiers, 86000 Poitiers, France
5
National Center for Food Technology and Safety, CNTA, 31570 San Adrian, Spain
6
Plantas Medicinales y Complementos Alimenticios, S.A. (PLAMECA), 08780 Palleja, Spain
*
Author to whom correspondence should be addressed.
Academic Editor: Dimitrios G. Fatouros
Pharmaceutics 2021, 13(3), 361; https://doi.org/10.3390/pharmaceutics13030361
Received: 11 February 2021 / Revised: 28 February 2021 / Accepted: 3 March 2021 / Published: 9 March 2021
Curcumin is a natural compound obtained from turmeric root with high antioxidant and anti-inflammatory activities. However, clinical application of curcumin has been limited due to its low solubility and bioavailability and rapid metabolism and degradation. This study was conducted to evaluate the effect of curcumin incorporation in zein nanoparticles on the pharmacokinetic parameters of systemic curcumin in plasma. Wistar rats were administered a single oral dose of 250 mg/kg of standard curcumin (control) or nanocurcumin (zein-based nanoparticles, Nucaps). The proposed new formulation was also compared with two commercially available curcumin complexes. Blood samples were collected at different times, and plasma levels were determined using HPLC-MS/MS. Overall, nanocurcumin (Nucaps) formulation was well tolerated and showed a 9-fold increase in oral bioavailability when compared to the standard curcumin natural extract. In addition, the nanoparticles prepared in this study demonstrated a bioavailability profile superior to that of other bioavailability-enhanced curcumin complexes currently available in the marketplace. Thus, our nanoparticle-based formulation has shown great potential as a nutraceutical for the oral administration of curcumin. View Full-Text
Keywords: antioxidant; bioavailability; curcumin; curcuminoid; nanoparticles antioxidant; bioavailability; curcumin; curcuminoid; nanoparticles
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MDPI and ACS Style

Brotons-Canto, A.; González-Navarro, C.J.; Gil, A.G.; Asin-Prieto, E.; Saiz, M.J.; Llabrés, J.M. Zein Nanoparticles Improve the Oral Bioavailability of Curcumin in Wistar Rats. Pharmaceutics 2021, 13, 361. https://doi.org/10.3390/pharmaceutics13030361

AMA Style

Brotons-Canto A, González-Navarro CJ, Gil AG, Asin-Prieto E, Saiz MJ, Llabrés JM. Zein Nanoparticles Improve the Oral Bioavailability of Curcumin in Wistar Rats. Pharmaceutics. 2021; 13(3):361. https://doi.org/10.3390/pharmaceutics13030361

Chicago/Turabian Style

Brotons-Canto, Ana, Carlos J. González-Navarro, Ana G. Gil, Eduardo Asin-Prieto, María J. Saiz, and Josep M. Llabrés. 2021. "Zein Nanoparticles Improve the Oral Bioavailability of Curcumin in Wistar Rats" Pharmaceutics 13, no. 3: 361. https://doi.org/10.3390/pharmaceutics13030361

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