Next Article in Journal
Protective Effect of Mitochondria-Targeted Antioxidants against Inflammatory Response to Lipopolysaccharide Challenge: A Review
Next Article in Special Issue
Novel Anticancer Strategies
Previous Article in Journal
TLR Agonists as Vaccine Adjuvants Targeting Cancer and Infectious Diseases
Previous Article in Special Issue
Therapeutic Approaches for Metastases from Colorectal Cancer and Pancreatic Ductal Carcinoma
Review

Delivery of Natural Agents by Means of Mesoporous Silica Nanospheres as a Promising Anticancer Strategy

1
Laboratory of Nanostructures and Nanomedicine, Institute of High Pressure Physics, Polish Academy of Sciences, Sokolowska 29/37, 01-142 Warsaw, Poland
2
Medicinal and Aromatic Plants Research Department, Pharmaceutical and Drug Industries Research Division, National Research Centre (NRC), 33 El-Behouth St., Dokki 12622, Giza, Egypt
*
Authors to whom correspondence should be addressed.
Academic Editors: Hassan Bousbaa and Stefano Giovagnoli
Pharmaceutics 2021, 13(2), 143; https://doi.org/10.3390/pharmaceutics13020143
Received: 30 November 2020 / Revised: 12 January 2021 / Accepted: 14 January 2021 / Published: 22 January 2021
(This article belongs to the Special Issue Novel Anticancer Strategies)
Natural prodrugs derived from different natural origins (e.g., medicinal plants, microbes, animals) have a long history in traditional medicine. They exhibit a broad range of pharmacological activities, including anticancer effects in vitro and in vivo. They have potential as safe, cost-effective treatments with few side effects, but are lacking in solubility, bioavailability, specific targeting and have short half-lives. These are barriers to clinical application. Nanomedicine has the potential to offer solutions to circumvent these limitations and allow the use of natural pro-drugs in cancer therapy. Mesoporous silica nanoparticles (MSNs) of various morphology have attracted considerable attention in the search for targeted drug delivery systems. MSNs are characterized by chemical stability, easy synthesis and functionalization, large surface area, tunable pore sizes and volumes, good biocompatibility, controlled drug release under different conditions, and high drug-loading capacity, enabling multifunctional purposes. In vivo pre-clinical evaluations, a significant majority of results indicate the safety profile of MSNs if they are synthesized in an optimized way. Here, we present an overview of synthesis methods, possible surface functionalization, cellular uptake, biodistribution, toxicity, loading strategies, delivery designs with controlled release, and cancer targeting and discuss the future of anticancer nanotechnology-based natural prodrug delivery systems. View Full-Text
Keywords: mesoporous silica nanoparticles; controlled release; drug delivery systems; anticancer natural prodrugs; natural products; cancer targeting; nanoformulations/nanomedicine applications mesoporous silica nanoparticles; controlled release; drug delivery systems; anticancer natural prodrugs; natural products; cancer targeting; nanoformulations/nanomedicine applications
Show Figures

Figure 1

MDPI and ACS Style

AbouAitah, K.; Lojkowski, W. Delivery of Natural Agents by Means of Mesoporous Silica Nanospheres as a Promising Anticancer Strategy. Pharmaceutics 2021, 13, 143. https://doi.org/10.3390/pharmaceutics13020143

AMA Style

AbouAitah K, Lojkowski W. Delivery of Natural Agents by Means of Mesoporous Silica Nanospheres as a Promising Anticancer Strategy. Pharmaceutics. 2021; 13(2):143. https://doi.org/10.3390/pharmaceutics13020143

Chicago/Turabian Style

AbouAitah, Khaled, and Witold Lojkowski. 2021. "Delivery of Natural Agents by Means of Mesoporous Silica Nanospheres as a Promising Anticancer Strategy" Pharmaceutics 13, no. 2: 143. https://doi.org/10.3390/pharmaceutics13020143

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop