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Review

Biomimetic Nanoparticles Coated with Bacterial Outer Membrane Vesicles as a New-Generation Platform for Biomedical Applications

Department of Chemistry and Chemistry Institute for Functional Materials, Pusan National University, Busan 46241, Korea
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Author to whom correspondence should be addressed.
Academic Editor: Cheong-Weon Cho
Pharmaceutics 2021, 13(11), 1887; https://doi.org/10.3390/pharmaceutics13111887
Received: 8 October 2021 / Revised: 3 November 2021 / Accepted: 4 November 2021 / Published: 7 November 2021
(This article belongs to the Special Issue Advanced Nanoscience of Biomaterials for Biomedical Applications)
The biomedical field is currently reaping the benefits of research on biomimetic nanoparticles (NPs), which are synthetic nanoparticles fabricated with natural cellular materials for nature-inspired biomedical applications. These camouflage NPs are capable of retaining not only the physiochemical properties of synthetic nanoparticles but also the original biological functions of the cellular materials. Accordingly, NPs coated with cell-derived membrane components have achieved remarkable growth as prospective biomedical materials. Particularly, bacterial outer membrane vesicle (OMV), which is a cell membrane coating material for NPs, is regarded as an important molecule that can be employed in several biomedical applications, including immune response activation, cancer therapeutics, and treatment for bacterial infections with photothermal activity. The currently available cell membrane-coated NPs are summarized in this review. Furthermore, the general features of bacterial OMVs and several multifunctional NPs that could serve as inner core materials in the coating strategy are presented, and several methods that can be used to prepare OMV-coated NPs (OMV-NPs) and their characterization are highlighted. Finally, some perspectives of OMV-NPs in various biomedical applications for future potential breakthrough are discussed. This in-depth review, which includes potential challenges, will encourage researchers to fabricate innovative and improvised, new-generation biomimetic materials through future biomedical applications. View Full-Text
Keywords: bacterial outer membrane vesicles (OMVs); membrane coating; biomimetic nanoparticles; biomedical applications bacterial outer membrane vesicles (OMVs); membrane coating; biomimetic nanoparticles; biomedical applications
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MDPI and ACS Style

Naskar, A.; Cho, H.; Lee, S.; Kim, K.-s. Biomimetic Nanoparticles Coated with Bacterial Outer Membrane Vesicles as a New-Generation Platform for Biomedical Applications. Pharmaceutics 2021, 13, 1887. https://doi.org/10.3390/pharmaceutics13111887

AMA Style

Naskar A, Cho H, Lee S, Kim K-s. Biomimetic Nanoparticles Coated with Bacterial Outer Membrane Vesicles as a New-Generation Platform for Biomedical Applications. Pharmaceutics. 2021; 13(11):1887. https://doi.org/10.3390/pharmaceutics13111887

Chicago/Turabian Style

Naskar, Atanu, Hyejin Cho, Sohee Lee, and Kwang-sun Kim. 2021. "Biomimetic Nanoparticles Coated with Bacterial Outer Membrane Vesicles as a New-Generation Platform for Biomedical Applications" Pharmaceutics 13, no. 11: 1887. https://doi.org/10.3390/pharmaceutics13111887

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