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Article

Optimized Birch Bark Extract-Loaded Colloidal Dispersion Using Hydrogenated Phospholipids as Stabilizer

Department of Pharmaceutical Technology, Eberhard Karls University, Auf der Morgenstelle 8, 72076 Tuebingen, Germany
*
Author to whom correspondence should be addressed.
These authors contributed equally to this paper.
Pharmaceutics 2020, 12(9), 832; https://doi.org/10.3390/pharmaceutics12090832
Received: 10 July 2020 / Revised: 28 August 2020 / Accepted: 29 August 2020 / Published: 31 August 2020
(This article belongs to the Special Issue Advanced Colloidal Systems for Multimodal Drug Delivery)
This study investigated the formulation and processing of aqueous colloidal dispersions containing a birch bark dry extract (TE) as the active substance and hydrogenated phospholipids (Phospholipon 90H) as stabilizer, which can be used in the preparation of electrospun wound dressings. Colloidal dispersions manufactured using a two-stage homogenization process had a bimodal particle size distribution, which was most significantly (p < 0.0001) affected by the phospholipid content. The size of the single particles decreased from an average particle size of about 4 µm to a particle size of approximately 400 nm. Dynamic interfacial tension studies performed using a profile analysis tensiometer (PAT) showed that the phospholipids strongly declined the interfacial tension, whereas a further decrease was observed when phospholipids were combined with birch bark extract. Interfacial viscoelasticity properties analyzed using the oscillating drop technique resulted in an increase of both interfacial elasticity and viscosity values. These results indicated that the phospholipids are preferentially located at the lipophilic/water interface and a stable film is formed. Furthermore, the results point to a synergistic interaction between phospholipids and TE. Confocal Raman microscopy (CRM) suggested that the TE is predominantly located in the oil phase and the phospholipids at the interface. View Full-Text
Keywords: colloidal dispersions; birch bark extract; phospholipids; sunflower oil; high-pressure homogenization; interfacial rheology colloidal dispersions; birch bark extract; phospholipids; sunflower oil; high-pressure homogenization; interfacial rheology
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MDPI and ACS Style

Mwiiri, F.K.; Daniels, R. Optimized Birch Bark Extract-Loaded Colloidal Dispersion Using Hydrogenated Phospholipids as Stabilizer. Pharmaceutics 2020, 12, 832. https://doi.org/10.3390/pharmaceutics12090832

AMA Style

Mwiiri FK, Daniels R. Optimized Birch Bark Extract-Loaded Colloidal Dispersion Using Hydrogenated Phospholipids as Stabilizer. Pharmaceutics. 2020; 12(9):832. https://doi.org/10.3390/pharmaceutics12090832

Chicago/Turabian Style

Mwiiri, Francis K., and Rolf Daniels. 2020. "Optimized Birch Bark Extract-Loaded Colloidal Dispersion Using Hydrogenated Phospholipids as Stabilizer" Pharmaceutics 12, no. 9: 832. https://doi.org/10.3390/pharmaceutics12090832

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